Blood bupivacaine concentrations after a combined single-shot sciatic block and a continuous femoral nerve block in pediatric patients: A prospective observational study

Santhanam Suresh, Gildasio S. De Oliveira*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours. The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.

Original languageEnglish (US)
Pages (from-to)1591-1593
Number of pages3
JournalAnesthesia and analgesia
Volume124
Issue number5
DOIs
Publication statusPublished - Jan 1 2017

    Fingerprint

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this