TY - JOUR
T1 - Blood bupivacaine concentrations after a combined single-shot sciatic block and a continuous femoral nerve block in pediatric patients
T2 - A prospective observational study
AU - Suresh, Santhanam
AU - De Oliveira, Gildasio S.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours. The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.
AB - We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours. The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.
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U2 - 10.1213/ANE.0000000000001531
DO - 10.1213/ANE.0000000000001531
M3 - Review article
C2 - 28431423
AN - SCOPUS:85018263831
VL - 124
SP - 1591
EP - 1593
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 5
ER -