Blood cultures in the emergency department evaluation of childhood pneumonia

Samir S. Shah, Maria H. Dugan, Louis M. Bell, Robert W. Grundmeier, Todd A. Florin, Elizabeth M. Hines, Joshua P. Metlay

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Blood cultures are frequently obtained in the emergency department (ED) evaluation of children with community-acquired pneumonia (CAP). Objectives: To determine the prevalence of bacteremia in children presenting to the ED with CAP, identify subgroups at increased risk for bacteremia, and quantify the effect of positive blood cultures on management. Methods: This case-control study was nested within a cohort of children followed up at 35 pediatric practices. Patients from this cohort who were ≤18 years of age, evaluated in the ED in 2006-2007, and diagnosed with CAP were eligible. Cases were those with bacteremia. Controls included those with negative blood cultures and those without blood cultures performed. Results: A total of 877 (9.6%) of 9099 children with CAP were evaluated in the ED. The mean age was 3.6 years; 53% were male. Blood cultures were obtained from 291 children (33.2%). Overall, the prevalence of bacteremia was 2.1% (95% confidence interval [CI]: 0.8%-4.4%). Bacteremia occurred in 2.6% (95% CI: 1.0%-5.6%) with an infiltrate on chest radiograph and in 13.0% (95% CI: 2.8%-33.6%) with complicated pneumonia. Streptococcus pneumoniae accounted for 4 of the 6 cases of bacteremia. Blood culture results altered management in 5 of the 6 bacteremic patients; 1 had an appropriate broadening and 4 had an appropriate narrowing of coverage. The contamination rate was 1.0% (95% CI: 0.2%-3.0%). Conclusion: Children presenting to the ED for evaluation of CAP are at low-risk for bacteremia. Although positive blood cultures frequently altered clinical management, the overall impact was small because of the low prevalence of bacteremia.

Original languageEnglish (US)
Pages (from-to)475-479
Number of pages5
JournalPediatric Infectious Disease Journal
Volume30
Issue number6
DOIs
StatePublished - Jan 1 2011

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Bacteremia
Hospital Emergency Service
Pneumonia
Confidence Intervals
Blood Culture
Streptococcus pneumoniae
Case-Control Studies
Thorax
Pediatrics

Keywords

  • Bacteremia
  • Streptococcus pneumoniae
  • child
  • epidemiology
  • pneumonia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Shah, S. S., Dugan, M. H., Bell, L. M., Grundmeier, R. W., Florin, T. A., Hines, E. M., & Metlay, J. P. (2011). Blood cultures in the emergency department evaluation of childhood pneumonia. Pediatric Infectious Disease Journal, 30(6), 475-479. https://doi.org/10.1097/INF.0b013e31820a5adb
Shah, Samir S. ; Dugan, Maria H. ; Bell, Louis M. ; Grundmeier, Robert W. ; Florin, Todd A. ; Hines, Elizabeth M. ; Metlay, Joshua P. / Blood cultures in the emergency department evaluation of childhood pneumonia. In: Pediatric Infectious Disease Journal. 2011 ; Vol. 30, No. 6. pp. 475-479.
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Blood cultures in the emergency department evaluation of childhood pneumonia. / Shah, Samir S.; Dugan, Maria H.; Bell, Louis M.; Grundmeier, Robert W.; Florin, Todd A.; Hines, Elizabeth M.; Metlay, Joshua P.

In: Pediatric Infectious Disease Journal, Vol. 30, No. 6, 01.01.2011, p. 475-479.

Research output: Contribution to journalArticle

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AU - Shah, Samir S.

AU - Dugan, Maria H.

AU - Bell, Louis M.

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N2 - Background: Blood cultures are frequently obtained in the emergency department (ED) evaluation of children with community-acquired pneumonia (CAP). Objectives: To determine the prevalence of bacteremia in children presenting to the ED with CAP, identify subgroups at increased risk for bacteremia, and quantify the effect of positive blood cultures on management. Methods: This case-control study was nested within a cohort of children followed up at 35 pediatric practices. Patients from this cohort who were ≤18 years of age, evaluated in the ED in 2006-2007, and diagnosed with CAP were eligible. Cases were those with bacteremia. Controls included those with negative blood cultures and those without blood cultures performed. Results: A total of 877 (9.6%) of 9099 children with CAP were evaluated in the ED. The mean age was 3.6 years; 53% were male. Blood cultures were obtained from 291 children (33.2%). Overall, the prevalence of bacteremia was 2.1% (95% confidence interval [CI]: 0.8%-4.4%). Bacteremia occurred in 2.6% (95% CI: 1.0%-5.6%) with an infiltrate on chest radiograph and in 13.0% (95% CI: 2.8%-33.6%) with complicated pneumonia. Streptococcus pneumoniae accounted for 4 of the 6 cases of bacteremia. Blood culture results altered management in 5 of the 6 bacteremic patients; 1 had an appropriate broadening and 4 had an appropriate narrowing of coverage. The contamination rate was 1.0% (95% CI: 0.2%-3.0%). Conclusion: Children presenting to the ED for evaluation of CAP are at low-risk for bacteremia. Although positive blood cultures frequently altered clinical management, the overall impact was small because of the low prevalence of bacteremia.

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