Blood group antigen expression in dysplasia and adenocarcinoma of the prostate

E. J. Perlman, I. E. Epstein

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Blood groups antigens have been implicated as markers in oncogenesis; however, studies of blood group antigen expression in the prostate have yielded conflicting data. This study examined the expression of A, B, H,X, and Lewis antigens in 30 prostates removed for adenocarcinoma, by utilizing monoclonal antibodies, Ulex europaeus agglutin I (for H type-2 chains), and the secretor status. A, B, and Ulex staining of the normal prostate most commonly demonstrated strong staining of 5-15% of cells. Staining of central and peripheral zones was similar, and nodules of hyperplasia showed no difference in staining. Antibodies to Lea, Leb, and X showed no staining or only pale staining of less than 10% of the normal prostatic epithelial cells. Ulex staining of intermediate and high-grade areas of tumor showed a diffuse staining pattern that was consistently greater than that of the normal glands. In contrast, low-grade tumors stained similarly to normal glands with Ulex. In 15 or 16 cases of dysplasia, Ulex staining was increased over normal and was similar to the adacent carcinoma. A, B, Lea, Leb, and X antigens were negative in adenocarcinoma and dysplasia. This study supports the hypothesis that dysplasia represents a premalignant lesion; it further suggests that concomitant with malignant transformation, a disturbance occurs in enzyme activity. The result is augmentation of H type-2 expression in dysplasia and less-differentiated adenocarcinomas, and a loss of A, B, Lea, and Leb expression in dysplasia and all carcinomas.

Original languageEnglish (US)
Pages (from-to)810-818
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume14
Issue number9
DOIs
StatePublished - Jan 1 1990

Keywords

  • Adenocarcinoma
  • Blood group antigens
  • Dysplasia
  • Lewis antigens
  • prostate

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Blood group antigen expression in dysplasia and adenocarcinoma of the prostate'. Together they form a unique fingerprint.

Cite this