Blood methylomics in response to arsenic exposure in a low-exposed US population

Xin Liu, Yinan Zheng, Wei Zhang, Xiao Zhang, Donald M. Lioyd-Jones, Andrea A. Baccarelli, Hongyan Ning, Myriam Fornage, Ka He, Kiang Liu, Lifang Hou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Exposure to arsenic (As) has been associated with a number of diseases such as cancers, cardiovascular diseases (CVD), and neurological disorders. To explore the possible underlying epigenetic mechanisms, a nested case-control study was conducted within the Coronary Artery Risk Development in Young Adults (CARDIA) study by randomly selecting 46 non-smoker and non-diabetic White participants with low (N=23) and high (N=23) As exposure based on toenail total As measures at examination year 2. We conducted methylomic profiling of white blood cell (WBC) DNA collected at examination year 15 using the Illumina HumanMethylation450 BeadChip, and performed association tests using multiple linear regression models adjusting for age, sex, and estimated WBC proportions. We observed 22 CpG sites with methylation levels associated with high As exposure at a nominal significance level of 10 -4. However, the statistical significance disappeared after correction for multiple testing. Some genes annotated by these 22 CpG sites are known to be involved in As-associated diseases. Replication in larger samples of individuals with low levels of As exposure will be required.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalJournal of Exposure Science and Environmental Epidemiology
Volume24
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • arsenic exposure
  • methylomic profiling
  • prospective association

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

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