Blood Pressure in Pregnancy and Hypertension 10-14 Years after Delivery

Kartik K. Venkatesh*, William A. Grobman, Jiqiang Wu, Maged M. Costantine, Mark B. Landon, Denise Scholtens, William Lowe, Nilay S. Shah, Natalie A. Cameron, Sadiya S. Khan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the association between blood pressure (BP) in the early third trimester and hypertension 10-14 years after delivery per American College of Cardiology and American Heart Association recommendations. We conducted a secondary analysis using the prospective HAPO FUS (Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study) in patients without a chronic hypertension diagnosis. The exposure and outcome were systolic and diastolic BP measured in the early third trimester and 10-14 years after delivery, respectively. Among 4,697 participants in the HAPO FUS, at 10-14 years after delivery (median age 41.6 years), 8.3% had elevated BP, 14.1% had stage 1 hypertension, and 6.1% had stage 2 hypertension. Compared with normal BP, elevated BP in the early third trimester was associated with an increased risk of stage 1 hypertension (adjusted odds ratio [aOR] 2.76; 95% CI, 1.91-4.00) and stage 2 hypertension (aOR 3.76; 95% CI, 2.28-6.19). Stage 1 hypertension was associated with an increased risk of stage 2 hypertension (aOR 6.16; 4.24, 8.94). Pregnant individuals with high BP in the third trimester were at increased risk of developing hypertension 10-14 years after delivery.

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalObstetrics and gynecology
Volume145
Issue number2
DOIs
StatePublished - Feb 1 2025

Funding

The Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO FUS) was conducted by the HAPO FUS Cooperative Research Group and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the American Diabetes Association. The HAPO Study was supported by the National Institute of Child Health and Human Development and American Diabetes Association. The data from the HAPO FUS reported here were supplied by the NIDDK Central Repository. This manuscript was prepared in collaboration with some of the investigators of the HAPO FUS and does not necessarily reflect the opinions or views of the HAPO FUS, the NIDDK Central Repository, or the NIDDK. Dr. Venkatesh was supported by the Care Innovation and Community Improvement Program at The Ohio State University. Dr Khan was supported by NHLBI grant #HL161514. Dr. Shah was supported by American Heart Association grant #24CDA1266732.

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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