Blood pressure variability and the development of early neurological deterioration following acute ischemic stroke

Jong Won Chung*, Nayoung Kim, Jihoon Kang, Su Hyun Park, Wook Joo Kim, Youngchai Ko, Jung Hyun Park, Ji Sung Lee, Juneyoung Lee, Mi Hwa Yang, Myung Suk Jang, Chang Wan Oh, O. Ki Kwon, Cheol Kyu Jung, Beom Joon Kim, Moon Ku Han, Philip B. Gorelick, Hee Joon Bae

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Objectives: Early neurological deterioration (END) is a common condition associated with poor outcome after acute ischemic stroke. We studied association between blood pressure (BP) variability and development of END. Methods: In this retrospective observational study, we studied a consecutive series of patients hospitalized for acute ischemic stroke within 24h of onset. The primary outcome of interest was the development of END according to predefined criteria within the first 72h of stroke onset. During this period, the mean, maximum (max), and minimum (min) values for the SBP and DBP were measured. The following parameters of BP variability were calculated for the SBP and DBP: the difference between the maximum and minimum (max-min), the SD, and the coefficient of variation. Results: Of the 1161 patients enrolled in the study (mean age, 67.5±13.3 years; 59.6% men), 210 (18.1%) developed END. All of the BP variability parameters were linearly associated with END independent of mean BP and potential clinical variables (P values<0.05 on likelihood ratio tests for trend), except for SBPmax-min. Among the other BP parameters, SBPmean, SBPmax, DBPmax, and DBPmin were independently associated with END. After adjustments for potential confounders, the odds for END increased 14-21% with each increase of one standard deviation in the BP variability parameter. Conclusion: BP variability is independently and linearly associated with the development of neurologic deterioration in acute stage of ischemic stroke.

Original languageEnglish (US)
Pages (from-to)2099-2106
Number of pages8
JournalJournal of hypertension
Issue number10
StatePublished - 2015


  • blood pressure
  • cerebral infarction
  • prognosis
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology
  • Internal Medicine


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