BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

John D. Crispino*, Michelle M. Le Beau

*Corresponding author for this work

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

Original languageEnglish (US)
Pages (from-to)567-568
Number of pages2
JournalCancer Cell
Volume22
Issue number5
DOIs
StatePublished - Nov 13 2012

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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