BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

John D. Crispino; Michelle M. Le Beau

doi:10.1016/j.ccr.2012.10.008

BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

John D. Crispino^*, Michelle M. Le Beau

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

Original language	English (US)
Pages (from-to)	567-568
Number of pages	2
Journal	Cancer cell
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.ccr.2012.10.008
State	Published - Nov 13 2012

ASJC Scopus subject areas

Oncology
Cancer Research
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2012.10.008

Cite this

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title = "BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia",

abstract = "In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.",

author = "Crispino, {John D.} and {Le Beau}, {Michelle M.}",

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AU - Crispino, John D.

AU - Le Beau, Michelle M.

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Y1 - 2012/11/13

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AB - In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

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DO - 10.1016/j.ccr.2012.10.008

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JO - Cancer cell

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BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

Abstract

ASJC Scopus subject areas

UN SDGs

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