BODIPYs with Photoactivatable Fluorescence

Yang Zhang*, Yeting Zheng, Yasniel Meana, Françisco M. Raymo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The borondipyrromethene (BODIPY) chromophore is a versatile platform for the construction of photoresponsive dyes with unique properties. Specifically, its covalent connection to a photocleavable group can be exploited to engineer compounds with photoswitchable fluorescence. The resulting photoactivatable fluorophores can increase their emission intensity or shift their emission wavelengths in response to switching. Such changes permit the spatiotemporal control of fluorescence with optical stimulations and the implementation of imaging strategies that would be impossible to replicate with conventional fluorophores. Indeed, BODIPYs with photoactivatable fluorescence enable the selective highlighting of intracellular targets, the nanoscaled visualization of sub-cellular components, the real-time monitoring of dynamic events and the photochemical writing of optical barcodes.

Original languageEnglish (US)
Pages (from-to)11257-11267
Number of pages11
JournalChemistry - A European Journal
Issue number44
StatePublished - Aug 5 2021


  • fluorescence
  • imaging
  • photoactivatable fluorophores
  • photocages

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • Organic Chemistry


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