Body composition and diabetes risk in South Asians: Findings from the Masala and MeSA studies

Elena Flowers*, Feng Lin, Namratha R Kandula, Matthew Allison, Jeffrey J. Carr, Jingzhong Ding, Ravi Shah, Kiang Liu, David Herrington, Alka M. Kanaya

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE South Asians have a higher prevalence of type 2 diabetes compared with other race/ ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population. RESEARCH DESIGN AND METHODS This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants (n = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort. RESULTS In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA (P < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups (P < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship. CONCLUSIONS We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.

Original languageEnglish (US)
Pages (from-to)946-953
Number of pages8
JournalDiabetes care
Volume42
Issue number5
DOIs
StatePublished - May 1 2019

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Body Composition
Type 2 Diabetes Mellitus
Atherosclerosis
Ethnic Groups
Fasting
Cohort Studies
Logistic Models
Body Weights and Measures
Glucose
Adipose Tissue
Prospective Studies
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Flowers, E., Lin, F., Kandula, N. R., Allison, M., Carr, J. J., Ding, J., ... Kanaya, A. M. (2019). Body composition and diabetes risk in South Asians: Findings from the Masala and MeSA studies. Diabetes care, 42(5), 946-953. https://doi.org/10.2337/dc18-1510
Flowers, Elena ; Lin, Feng ; Kandula, Namratha R ; Allison, Matthew ; Carr, Jeffrey J. ; Ding, Jingzhong ; Shah, Ravi ; Liu, Kiang ; Herrington, David ; Kanaya, Alka M. / Body composition and diabetes risk in South Asians : Findings from the Masala and MeSA studies. In: Diabetes care. 2019 ; Vol. 42, No. 5. pp. 946-953.
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abstract = "OBJECTIVE South Asians have a higher prevalence of type 2 diabetes compared with other race/ ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population. RESEARCH DESIGN AND METHODS This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants (n = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort. RESULTS In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA (P < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups (P < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship. CONCLUSIONS We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.",
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Flowers, E, Lin, F, Kandula, NR, Allison, M, Carr, JJ, Ding, J, Shah, R, Liu, K, Herrington, D & Kanaya, AM 2019, 'Body composition and diabetes risk in South Asians: Findings from the Masala and MeSA studies', Diabetes care, vol. 42, no. 5, pp. 946-953. https://doi.org/10.2337/dc18-1510

Body composition and diabetes risk in South Asians : Findings from the Masala and MeSA studies. / Flowers, Elena; Lin, Feng; Kandula, Namratha R; Allison, Matthew; Carr, Jeffrey J.; Ding, Jingzhong; Shah, Ravi; Liu, Kiang; Herrington, David; Kanaya, Alka M.

In: Diabetes care, Vol. 42, No. 5, 01.05.2019, p. 946-953.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body composition and diabetes risk in South Asians

T2 - Findings from the Masala and MeSA studies

AU - Flowers, Elena

AU - Lin, Feng

AU - Kandula, Namratha R

AU - Allison, Matthew

AU - Carr, Jeffrey J.

AU - Ding, Jingzhong

AU - Shah, Ravi

AU - Liu, Kiang

AU - Herrington, David

AU - Kanaya, Alka M.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - OBJECTIVE South Asians have a higher prevalence of type 2 diabetes compared with other race/ ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population. RESEARCH DESIGN AND METHODS This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants (n = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort. RESULTS In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA (P < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups (P < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship. CONCLUSIONS We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.

AB - OBJECTIVE South Asians have a higher prevalence of type 2 diabetes compared with other race/ ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population. RESEARCH DESIGN AND METHODS This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants (n = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort. RESULTS In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA (P < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups (P < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship. CONCLUSIONS We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.

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