Body fat distribution with long-term dietary restriction in adult male rhesus macaques

Ricki J. Colman, Jon J. Ramsey, Ellen B. Roecker, Thomas Havighurst, John C. Hudson, Joseph W. Kemnitz*

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Dietary restriction (DR) is the only intervention that has been shown to increase average and median life span in laboratory rodents. The effect of long-term, moderate DR on body composition and fat distribution was evaluated in male rhesus monkeys. Thirty animals (8-14 years of age) fed either 30% less than baseline intake (R, n = 15) or allowed to eat to satiety (C, n = 15), have been assessed semiannually using somatometrics and dual-energy x- ray absorptiometry (DXA) for 7.5 years. R subjects have reduced body weight (p < .0001), total body fat (p < .0001), and percentage body fat located in the abdominal region (p < .05). In addition, there has been a sustained reduction in plasma leptin concentrations (p < .001). These findings suggest reduced risk for common morbidities, such as insulin resistance, dyslipidemia, and type 2 diabetes mellitus, that are associated with advancing age and increased levels of body fat, especially in the visceral depot.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume54
Issue number7
DOIs
StatePublished - Jan 1 1999

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Body Fat Distribution
Macaca mulatta
Adipose Tissue
Dyslipidemias
Leptin
Body Composition
Type 2 Diabetes Mellitus
Insulin Resistance
Rodentia
Body Weight
X-Rays
Morbidity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Colman, Ricki J. ; Ramsey, Jon J. ; Roecker, Ellen B. ; Havighurst, Thomas ; Hudson, John C. ; Kemnitz, Joseph W. / Body fat distribution with long-term dietary restriction in adult male rhesus macaques. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 1999 ; Vol. 54, No. 7.
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Body fat distribution with long-term dietary restriction in adult male rhesus macaques. / Colman, Ricki J.; Ramsey, Jon J.; Roecker, Ellen B.; Havighurst, Thomas; Hudson, John C.; Kemnitz, Joseph W.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 54, No. 7, 01.01.1999.

Research output: Contribution to journalArticle

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