Body fat distribution with long-term dietary restriction in adult male rhesus macaques

Ricki J. Colman, Jon J. Ramsey, Ellen B. Roecker, Thomas Havighurst, John C. Hudson, Joseph W. Kemnitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Dietary restriction (DR) is the only intervention that has been shown to increase average and median life span in laboratory rodents. The effect of long-term, moderate DR on body composition and fat distribution was evaluated in male rhesus monkeys. Thirty animals (8-14 years of age) fed either 30% less than baseline intake (R, n = 15) or allowed to eat to satiety (C, n = 15), have been assessed semiannually using somatometrics and dual-energy x- ray absorptiometry (DXA) for 7.5 years. R subjects have reduced body weight (p < .0001), total body fat (p < .0001), and percentage body fat located in the abdominal region (p < .05). In addition, there has been a sustained reduction in plasma leptin concentrations (p < .001). These findings suggest reduced risk for common morbidities, such as insulin resistance, dyslipidemia, and type 2 diabetes mellitus, that are associated with advancing age and increased levels of body fat, especially in the visceral depot.

Original languageEnglish (US)
Pages (from-to)B283-B290
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume54
Issue number7
DOIs
StatePublished - Jul 1999

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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