Body fluid dynamics: Back to the future

Gautam Bhave*, Eric G. Neilson

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

119 Scopus citations


Pioneering investigations conducted over a half century ago on tonicity, transcapillary fluid exchange, and the distribution of water and solute serve as a foundation for understanding the physiology of body fluid spaces. With passage of time, however, some of these concepts have lost their connectivity to more contemporary information. Here we examine the physical forces determining the compartmentalization of body fluid and its movement across capillary and cell membrane barriers, drawing particular attention to the interstitium operating as a dynamic interface for water and solute distribution rather than as a static reservoir. Newer work now supports an evolving model of body fluid dynamics that integrates exchangeable Na + stores and transcapillary dynamics with advances in interstitial matrix biology.

Original languageEnglish (US)
Pages (from-to)2166-2181
Number of pages16
JournalJournal of the American Society of Nephrology
Issue number12
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Nephrology


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