Bone complications among prostate cancer survivors: Long-term follow-up from the prostate cancer outcomes study

A. K. Morgans*, K. H. Fan, T. Koyama, P. C. Albertsen, M. Goodman, A. S. Hamilton, R. M. Hoffman, J. L. Stanford, A. M. Stroup, D. F. Penson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: To assess the relationship between androgen deprivation therapy (ADT) exposure and self-reported bone complications among men in a population-based cohort of prostate cancer survivors followed for 15 years after diagnosis.Methods:The Prostate Cancer Outcomes Study enrolled 3533 patients diagnosed with prostate cancer between 1994 and 1995. This analysis included participants with non-metastatic disease at the time of diagnosis who completed 15-year follow-up surveys to report development of fracture, and use of bone-related medications. The relationship between ADT duration and bone complications was assessed using multivariable logistic regression models.Results:Among 961 surviving men, 157 (16.3%) received prolonged ADT (>1 year), 120 (12.5%) received short-term ADT (≤1 year) and 684 (71.2%) did not receive ADT. Men receiving prolonged ADT had higher odds of fracture (OR 2.5; 95% confidence interval (CI): 1.1-5.7), bone mineral density testing (OR 5.9; 95% CI: 3.0-12) and bone medication use (OR 4.3; 95% CI: 2.3-8.0) than untreated men. Men receiving short-term ADT reported rates of fracture similar to untreated men. Half of men treated with prolonged ADT reported bone medication use.Conclusions:In this population-based cohort study with long-term follow-up, prolonged ADT use was associated with substantial risks of fracture, whereas short-term use was not. This information should be considered when weighing the advantages and disadvantages of ADT in men with prostate cancer.

Original languageEnglish (US)
Pages (from-to)338-342
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Issue number4
StatePublished - Dec 13 2014

ASJC Scopus subject areas

  • Urology
  • Oncology
  • Cancer Research


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