Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia

L. C. Dunlop, R. Powles, S. Singhal, J. G. Treleaven, G. J. Swansbury, S. Meller, C. R. Pinkerton, C. Horton, J. Mehta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Between 1986 and 1995, 19 patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia underwent 20 autologous (n = 9) or allogeneic (n = 11) blood or marrow transplant procedures in first (n = 12) or second (n = 3) remission, or in relapse (n = 5). Four patients died due to transplant-related causes, 11 relapsed at 3-39 months, one survives with disease which did not remit after transplant, and three are alive in continuous remission at 1, 26 and 65 months. Two of the relapsing patients are alive; one autografted patient after an allograft in second remission and one allografted patient after a donor leukocyte infusion. The projected overall survival is 37.5% at 3 years and 12.5% at 5 years. The 3-year probabilities of relapse and disease-free survival for autografted patients are 65.9% and 25.6% respectively, and for allografted patients, 63.4% and 21.8% respectively. The stage of the disease at the time of transplant or the type of transplant did not affect the outcome significantly, and late relapses beyond 3 years were seen after allogeneic as well as autologous transplantation. In our experience, the outcome of patients with Ph+ acute lymphoblastic leukemia continues to be poor despite high-dose therapy due to high relapse rates, and the development of additional measures to enhance the antileukemic efficacy of bone marrow transplantation is necessary.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalBone Marrow Transplantation
Volume17
Issue number3
StatePublished - Mar 1996

Keywords

  • Acute lymphoblastic leukaemia
  • Allogeneic bone marrow transplantation
  • Autologous bone marrow transplantation
  • Immunotherapy
  • Interferon-α
  • Peripheral blood stem cell transplantation
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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