Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis

Martin S. Tallman; Robert W. McGuffin; Celestia S. Higano; Gordon Starkebaum; Steven J. Collins; Harold Johnston; Jack W. Singer; David J. Perry; Arthur Kunath

doi:10.1002/ajh.2830240112

Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis

Martin S. Tallman, Robert W. McGuffin, Celestia S. Higano, Gordon Starkebaum, Steven J. Collins, Harold Johnston, Jack W. Singer^*, David J. Perry, Arthur Kunath

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A 34‐year‐old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA‐identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.

Original language	English (US)
Pages (from-to)	93-99
Number of pages	7
Journal	American Journal of Hematology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830240112
State	Published - Jan 1987

Keywords

bone marrow transplantation
diffuse eosinophilic fasciitis
myelodysplasia

ASJC Scopus subject areas

Hematology

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10.1002/ajh.2830240112

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title = "Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis",

abstract = "A 34‐year‐old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA‐identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.",

keywords = "bone marrow transplantation, diffuse eosinophilic fasciitis, myelodysplasia",

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AU - Tallman, Martin S.

AU - McGuffin, Robert W.

AU - Higano, Celestia S.

AU - Starkebaum, Gordon

AU - Collins, Steven J.

AU - Johnston, Harold

AU - Singer, Jack W.

AU - Perry, David J.

AU - Kunath, Arthur

PY - 1987/1

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N2 - A 34‐year‐old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA‐identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.

AB - A 34‐year‐old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA‐identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.

KW - bone marrow transplantation

KW - diffuse eosinophilic fasciitis

KW - myelodysplasia

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Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis

Abstract

Keywords

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