Transplante de medula óssea com incompatibilidade ABO major. Experiência da UTM do Centro de Lisboa do IPOFG.

Translated title of the contribution: Bone marrow transplantation with major ABO incompatibility. Experience at the bone marrow transplantation unit of the Center of Lisbon at the IPOFG

R. Coelho*, I. Cunha, I. Nolasco, A. Machado, M. Abecassis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Thirteen patients submitted to major ABO incompatible, HLA A and B identical, mixed lymphocyte culture negative bone marrow transplantation (BMT) were retrospectively evaluated. Gravity sedimentation by hydroxyethyl starch was used in almost all cases to deplete erythrocytes from bone marrow (12/13): a removal rate or 90%--corresponding to an erythrocyte residual volume of 27.4 rate ml--and a nucleated cell recovery of 76% (mean values) were obtained. All patients underwent a hyperhydration regimen and received corticosteroid prophylaxis before bone marrow infusion. Considering the most important immunohematological problems associated to this type of transplant we verified that seven patients developed minor complications, and among them only one had long term consequences. In comparison with the control group, ABO identical and with minor incompatibility, the study group had delayed onset of erythropoiesis and needed greater erythrocyte transfusion support. We concluded that major ABO incompatibility does not constitute a drawback to BMT success in most patients.

Translated title of the contributionBone marrow transplantation with major ABO incompatibility. Experience at the bone marrow transplantation unit of the Center of Lisbon at the IPOFG
Original languagePortuguese
Pages (from-to)79-81
Number of pages3
JournalActa médica portuguesa
Volume6
Issue number2
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Medicine(all)

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