TY - JOUR
T1 - Bone mineral content and prostate cancer risk
T2 - Data from the Baltimore Longitudinal Study of Aging
AU - Loeb, Stacy
AU - Carter, H. Ballentine
AU - Schaeffer, Edward M.
AU - Ling, Shari M.
AU - Kettermann, Anna
AU - Ferrucci, Luigi
AU - Metter, E. Jeffrey
PY - 2010/7
Y1 - 2010/7
N2 - Study Type - Aetiology (inception cohort) Level of Evidence2b OBJECTIVE To determine whether there might be differences in bone mineral content (BMC) between men who develop life-threatening prostate cancer and those who do not, as bone is a common site of prostate cancer metastases. SUBJECTS AND METHODS From 1973 to 1984, BMC was serially measured in 519 participants (778 observations) as part of a longitudinal study of ageing. We examined the association between serial BMC measurements with the development of overall and high-risk prostate cancer over the next one to three decades. For all prostate cancer cases, BMC was censored at the time of diagnosis. RESULTS During a median (range) overall follow-up of 21.1 (0.2-35.0) years after the last BMC measurement, 76 (14.6%) men were later diagnosed with prostate cancer (18 high-risk and 58 not high-risk). BMC declined with age to a greater extent in healthy controls than among men diagnosed with prostate cancer (P = 0.018, likelihood ratio test), and tended to decline less in high-risk than non-high-risk cases. CONCLUSION The distribution of BMC was significantly different between men who did and did not develop prostate cancer, over an extended follow-up. Specifically, BMC appeared to decline to a greater extent with age among healthy controls than in men with prostate cancer, especially high-risk disease. The biology underlying the lesser decline in BMC among men with prostate cancer remains unclear, but suggests that host factors in the bony milieu might be associated with prostate cancer development and progression.
AB - Study Type - Aetiology (inception cohort) Level of Evidence2b OBJECTIVE To determine whether there might be differences in bone mineral content (BMC) between men who develop life-threatening prostate cancer and those who do not, as bone is a common site of prostate cancer metastases. SUBJECTS AND METHODS From 1973 to 1984, BMC was serially measured in 519 participants (778 observations) as part of a longitudinal study of ageing. We examined the association between serial BMC measurements with the development of overall and high-risk prostate cancer over the next one to three decades. For all prostate cancer cases, BMC was censored at the time of diagnosis. RESULTS During a median (range) overall follow-up of 21.1 (0.2-35.0) years after the last BMC measurement, 76 (14.6%) men were later diagnosed with prostate cancer (18 high-risk and 58 not high-risk). BMC declined with age to a greater extent in healthy controls than among men diagnosed with prostate cancer (P = 0.018, likelihood ratio test), and tended to decline less in high-risk than non-high-risk cases. CONCLUSION The distribution of BMC was significantly different between men who did and did not develop prostate cancer, over an extended follow-up. Specifically, BMC appeared to decline to a greater extent with age among healthy controls than in men with prostate cancer, especially high-risk disease. The biology underlying the lesser decline in BMC among men with prostate cancer remains unclear, but suggests that host factors in the bony milieu might be associated with prostate cancer development and progression.
KW - Bone density
KW - Calcium
KW - Metastases
KW - Prostate cancer
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=77953197043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953197043&partnerID=8YFLogxK
U2 - 10.1111/j.1464-410X.2009.09109.x
DO - 10.1111/j.1464-410X.2009.09109.x
M3 - Article
C2 - 20067459
AN - SCOPUS:77953197043
SN - 1464-4096
VL - 106
SP - 28
EP - 31
JO - British Journal of Urology
JF - British Journal of Urology
IS - 1
ER -