Bone mineral density during treatment of central precocious puberty

E. Kirk Neely, Laura K. Bachrach, Raymond L. Hintz, Reema L. Habiby, Charles W. Slemenda, Lori Feezle, Ora H. Pescovitz

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Treatment of adults with gonadotropin releasing hormone analogs has resulted in rapid loss in bone mineral density (BMD). We measured lumbar and femoral neck BMD by dual-energy x-ray absorptiometry during 2 years of depot leuprolide therapy in 13 girls (mean age, 7.5 years; mean bone age, 10.9 years). At baseline, BMD was elevated for age and concordant with the advanced skeletal age. During therapy with gonadotropin releasing hormone analog, BMD values increased and BMD standard deviation scores for age and skeletal age did not change. (J PEDIATR 1995;127:819-22).

Original languageEnglish (US)
Pages (from-to)819-822
Number of pages4
JournalThe Journal of pediatrics
Volume127
Issue number5
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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