Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

K. Whang; D. R. Elenz; E. K. Nam; D. C. Tsai; C. H. Thomas; G. W. Nuber; M. K. Bowen; K. E. Healy

Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

K. Whang^*, D. R. Elenz, E. K. Nam, D. C. Tsai, C. H. Thomas, G. W. Nuber, M. K. Bowen, K. E. Healy

^*Corresponding author for this work

Orthopaedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

Original language	English (US)
Title of host publication	Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors	Anon
Publisher	Soc for Biomaterials
Number of pages	1
Volume	1
State	Published - Dec 1 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

Cite this

Whang, K., Elenz, D. R., Nam, E. K., Tsai, D. C., Thomas, C. H., Nuber, G. W., Bowen, M. K., & Healy, K. E. (1996). Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1). Soc for Biomaterials.

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title = "Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm",

abstract = "Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.",

author = "K. Whang and Elenz, {D. R.} and Nam, {E. K.} and Tsai, {D. C.} and Thomas, {C. H.} and Nuber, {G. W.} and Bowen, {M. K.} and Healy, {K. E.}",

year = "1996",

month = dec,

day = "1",

language = "English (US)",

volume = "1",

editor = "Anon",

booktitle = "Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium",

publisher = "Soc for Biomaterials",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

}

Whang, K, Elenz, DR, Nam, EK, Tsai, DC, Thomas, CH, Nuber, GW, Bowen, MK & Healy, KE 1996, Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.

Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm. / Whang, K.; Elenz, D. R.; Nam, E. K. et al.
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 Soc for Biomaterials, 1996.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

AU - Whang, K.

AU - Elenz, D. R.

AU - Nam, E. K.

AU - Tsai, D. C.

AU - Thomas, C. H.

AU - Nuber, G. W.

AU - Bowen, M. K.

AU - Healy, K. E.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

AB - Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

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M3 - Conference contribution

AN - SCOPUS:0030398297

VL - 1

BT - Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium

A2 - Anon, null

PB - Soc for Biomaterials

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

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ASJC Scopus subject areas

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