R and S isomers of 24-OH-D3 and 24,25-(OH)2D3 were tested for their effects on bone resorption in vitro. 24(R), 25-(OH)2D3 was more active than 24(S),25-(OH)2D3. Likewise, 24(R)-OH-D3 was more active than 24(S)-OH-D3. The bone resorbing activity of 24(R)-OH-D3 was equivalent to that of 25-OH-D3; 24(R),25-(OH)2D3 was somewhat less potent. The results indicate that there is discrimination between the isomers of these compounds at the level of the responding tissue.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Dec 1 1975|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology