Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3

P. H. Stern*, H. F. DeLuca, N. Ikekawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

R and S isomers of 24-OH-D3 and 24,25-(OH)2D3 were tested for their effects on bone resorption in vitro. 24(R), 25-(OH)2D3 was more active than 24(S),25-(OH)2D3. Likewise, 24(R)-OH-D3 was more active than 24(S)-OH-D3. The bone resorbing activity of 24(R)-OH-D3 was equivalent to that of 25-OH-D3; 24(R),25-(OH)2D3 was somewhat less potent. The results indicate that there is discrimination between the isomers of these compounds at the level of the responding tissue.

Original languageEnglish (US)
Pages (from-to)965-971
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume67
Issue number3
DOIs
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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