TY - JOUR
T1 - Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3
AU - Stern, P. H.
AU - DeLuca, H. F.
AU - Ikekawa, N.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - R and S isomers of 24-OH-D3 and 24,25-(OH)2D3 were tested for their effects on bone resorption in vitro. 24(R), 25-(OH)2D3 was more active than 24(S),25-(OH)2D3. Likewise, 24(R)-OH-D3 was more active than 24(S)-OH-D3. The bone resorbing activity of 24(R)-OH-D3 was equivalent to that of 25-OH-D3; 24(R),25-(OH)2D3 was somewhat less potent. The results indicate that there is discrimination between the isomers of these compounds at the level of the responding tissue.
AB - R and S isomers of 24-OH-D3 and 24,25-(OH)2D3 were tested for their effects on bone resorption in vitro. 24(R), 25-(OH)2D3 was more active than 24(S),25-(OH)2D3. Likewise, 24(R)-OH-D3 was more active than 24(S)-OH-D3. The bone resorbing activity of 24(R)-OH-D3 was equivalent to that of 25-OH-D3; 24(R),25-(OH)2D3 was somewhat less potent. The results indicate that there is discrimination between the isomers of these compounds at the level of the responding tissue.
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U2 - 10.1016/0006-291X(75)90769-X
DO - 10.1016/0006-291X(75)90769-X
M3 - Article
C2 - 1201085
AN - SCOPUS:0016718399
SN - 0006-291X
VL - 67
SP - 965
EP - 971
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -