Bortezomib in recurrent and/or refractory multiple myeloma: Initial clinical experience in patients with impaired renal function

Sundar Jagannath*, Bart Barlogie, James R. Berenson, Seema Singhal, Raymond Alexanian, Gordan Srkalovic, Robert Z. Orlowski, Paul G. Richardson, Jessica Anderson, Darrell Nix, Dixie L. Esseltine, Kenneth C. Anderson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

209 Scopus citations

Abstract

BACKGROUND. Bortezomib is a potent, reversible proteasome inhibitor that has been approved for the treatment of recurrent and/or refractory multiple myeloma, but its activity in patients with renal impairment has not been studied to date. METHODS. Response rates, safety, and 20S proteasome activity were assessed in relation to baseline creatinine clearance (CrCl) among patients with recurrent and/or refractory myeloma (n = 256 patients) who were treated with bortezomib in 2 Phase II trials. Bortezomib was administered by intravenous bolus on Days 1, 4, 8, and 11 of a 21-day cycle at 2 doses, 1.0 mg/m2 (n = 28 patients) and 1.3 mg/m2 (n = 228 patients). RESULTS. Of 10 patients with CrCl ≤ 30 mL/minute, 7 patients completed the protocol-specified 8 cycles of treatment; 4 patients received the 1.3 mg/m 2 bortezomib dose, and 3 patients received the 1.0 mg/m2 bortezomib dose. Using the European Group for Blood and Marrow Transplantation criteria, responses were assigned by an independent committee to 3 of the 10 patients (2 partial responses and 1 minimal response), a response rate similar to that of the overall treated population. Patients with CrCl > 80 mL/minute (n = 105 patients), 51-80 mL/ minute (n = 99 patients), and ≤ 50 mL/minute (n = 52 patients) had similar rates of discontinuation and similar adverse event profiles. Renal function did not appear to affect the 1-hour postdose proteasome inhibition or its recovery. CONCLUSIONS. Clinical experience in a limited number of patients with impaired renal function suggests that bortezomib provides clinical benefit with manageable toxicities in this high-risk population.

Original languageEnglish (US)
Pages (from-to)1195-1200
Number of pages6
JournalCancer
Volume103
Issue number6
DOIs
StatePublished - Mar 15 2005

Keywords

  • Bortezomib
  • Myeloma
  • Proteasome
  • Renal failure

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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