Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions

Jeong su Do, Gilles Foucras, Nobuhiko Kamada, Austin F. Schenk, Michael Shaw, Gabriel Nuñez, William E. Paul, Booki Min*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalCellular Immunology
Volume272
Issue number2
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Commensal antigen
  • FTY720
  • Homeostasis
  • Lymphopenia
  • Self antigen
  • T cell

ASJC Scopus subject areas

  • Immunology

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