Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence

Anne P. Cameron*, Abigail R. Smith, H. Henry Lai, Catherine S. Bradley, Alice B. Liu, Robert M. Merion, Brenda W. Gillespie, Cindy L. Amundsen, David Cella, James W. Griffith, Jonathan B. Wiseman, Karl J. Kreder, Kimberly S. Kenton, Margaret E. Helmuth, Matthew O. Fraser, J. Quentin Clemens, Ziya Kirkali, John W. Kusek, Nazema Y. Siddiqui

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and without urinary incontinence (UI) and among subtypes of UI. Methods: Women with LUTS seeking care at six U.S. tertiary care centers enrolled in prospective cohort study were studied. At baseline, participants completed the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Organ Prolapse/Incontinence Sexual Questionnaire (PISQ-IR), and PROMIS GI Diarrhea, Constipation, and Fecal Incontinence Scales. Results: Mean age among the 510 women was 56.4 ± 14.4 years. Women who reported UI (n = 420) had more diarrhea and constipation symptoms (mean scores 49.5 vs 46.2 [P = 0.01] and 51.9 vs 48.4 [P < 0.01], respectively) at baseline. Among sexually active women, mean PISQ-IR subscale scores were lower among those with UI (condition specific: 89.8 vs 96.7, P < 0.01; condition impact: 79.8 vs 92.5, P < 0.01). Women with mixed urinary incontinence (MUI) (n = 240) reported more prolapse symptoms, fecal incontinence, and worse sexual function compared to those with stress urinary incontinence (SUI) and urgency urinary incontinence (UUI). Conclusions: Women presenting with LUTS with UI reported significantly worse constipation, diarrhea, fecal incontinence, and sexual function compared to women without UI. In women with UI, sexual function and pelvic organ prolapse (POP) symptoms were worse in those with MUI compared to SUI and UUI.

Original languageEnglish (US)
Pages (from-to)2586-2596
Number of pages11
JournalNeurourology and Urodynamics
Volume37
Issue number8
DOIs
StatePublished - Nov 1 2018

Fingerprint

Pelvic Organ Prolapse
Urinary Incontinence
Fecal Incontinence
Lower Urinary Tract Symptoms
Constipation
Diarrhea
Pelvic Floor
Stress Urinary Incontinence
Prolapse
Tertiary Care Centers
Cohort Studies

Keywords

  • constipation
  • fecal incontinence
  • pelvic organ prolapse
  • urinary incontinence

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Cameron, A. P., Smith, A. R., Lai, H. H., Bradley, C. S., Liu, A. B., Merion, R. M., ... Siddiqui, N. Y. (2018). Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. Neurourology and Urodynamics, 37(8), 2586-2596. https://doi.org/10.1002/nau.23587
Cameron, Anne P. ; Smith, Abigail R. ; Lai, H. Henry ; Bradley, Catherine S. ; Liu, Alice B. ; Merion, Robert M. ; Gillespie, Brenda W. ; Amundsen, Cindy L. ; Cella, David ; Griffith, James W. ; Wiseman, Jonathan B. ; Kreder, Karl J. ; Kenton, Kimberly S. ; Helmuth, Margaret E. ; Fraser, Matthew O. ; Clemens, J. Quentin ; Kirkali, Ziya ; Kusek, John W. ; Siddiqui, Nazema Y. / Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. In: Neurourology and Urodynamics. 2018 ; Vol. 37, No. 8. pp. 2586-2596.
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abstract = "Aims: Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and without urinary incontinence (UI) and among subtypes of UI. Methods: Women with LUTS seeking care at six U.S. tertiary care centers enrolled in prospective cohort study were studied. At baseline, participants completed the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Organ Prolapse/Incontinence Sexual Questionnaire (PISQ-IR), and PROMIS GI Diarrhea, Constipation, and Fecal Incontinence Scales. Results: Mean age among the 510 women was 56.4 ± 14.4 years. Women who reported UI (n = 420) had more diarrhea and constipation symptoms (mean scores 49.5 vs 46.2 [P = 0.01] and 51.9 vs 48.4 [P < 0.01], respectively) at baseline. Among sexually active women, mean PISQ-IR subscale scores were lower among those with UI (condition specific: 89.8 vs 96.7, P < 0.01; condition impact: 79.8 vs 92.5, P < 0.01). Women with mixed urinary incontinence (MUI) (n = 240) reported more prolapse symptoms, fecal incontinence, and worse sexual function compared to those with stress urinary incontinence (SUI) and urgency urinary incontinence (UUI). Conclusions: Women presenting with LUTS with UI reported significantly worse constipation, diarrhea, fecal incontinence, and sexual function compared to women without UI. In women with UI, sexual function and pelvic organ prolapse (POP) symptoms were worse in those with MUI compared to SUI and UUI.",
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Cameron, AP, Smith, AR, Lai, HH, Bradley, CS, Liu, AB, Merion, RM, Gillespie, BW, Amundsen, CL, Cella, D, Griffith, JW, Wiseman, JB, Kreder, KJ, Kenton, KS, Helmuth, ME, Fraser, MO, Clemens, JQ, Kirkali, Z, Kusek, JW & Siddiqui, NY 2018, 'Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence', Neurourology and Urodynamics, vol. 37, no. 8, pp. 2586-2596. https://doi.org/10.1002/nau.23587

Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. / Cameron, Anne P.; Smith, Abigail R.; Lai, H. Henry; Bradley, Catherine S.; Liu, Alice B.; Merion, Robert M.; Gillespie, Brenda W.; Amundsen, Cindy L.; Cella, David; Griffith, James W.; Wiseman, Jonathan B.; Kreder, Karl J.; Kenton, Kimberly S.; Helmuth, Margaret E.; Fraser, Matthew O.; Clemens, J. Quentin; Kirkali, Ziya; Kusek, John W.; Siddiqui, Nazema Y.

In: Neurourology and Urodynamics, Vol. 37, No. 8, 01.11.2018, p. 2586-2596.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence

AU - Cameron, Anne P.

AU - Smith, Abigail R.

AU - Lai, H. Henry

AU - Bradley, Catherine S.

AU - Liu, Alice B.

AU - Merion, Robert M.

AU - Gillespie, Brenda W.

AU - Amundsen, Cindy L.

AU - Cella, David

AU - Griffith, James W.

AU - Wiseman, Jonathan B.

AU - Kreder, Karl J.

AU - Kenton, Kimberly S.

AU - Helmuth, Margaret E.

AU - Fraser, Matthew O.

AU - Clemens, J. Quentin

AU - Kirkali, Ziya

AU - Kusek, John W.

AU - Siddiqui, Nazema Y.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Aims: Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and without urinary incontinence (UI) and among subtypes of UI. Methods: Women with LUTS seeking care at six U.S. tertiary care centers enrolled in prospective cohort study were studied. At baseline, participants completed the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Organ Prolapse/Incontinence Sexual Questionnaire (PISQ-IR), and PROMIS GI Diarrhea, Constipation, and Fecal Incontinence Scales. Results: Mean age among the 510 women was 56.4 ± 14.4 years. Women who reported UI (n = 420) had more diarrhea and constipation symptoms (mean scores 49.5 vs 46.2 [P = 0.01] and 51.9 vs 48.4 [P < 0.01], respectively) at baseline. Among sexually active women, mean PISQ-IR subscale scores were lower among those with UI (condition specific: 89.8 vs 96.7, P < 0.01; condition impact: 79.8 vs 92.5, P < 0.01). Women with mixed urinary incontinence (MUI) (n = 240) reported more prolapse symptoms, fecal incontinence, and worse sexual function compared to those with stress urinary incontinence (SUI) and urgency urinary incontinence (UUI). Conclusions: Women presenting with LUTS with UI reported significantly worse constipation, diarrhea, fecal incontinence, and sexual function compared to women without UI. In women with UI, sexual function and pelvic organ prolapse (POP) symptoms were worse in those with MUI compared to SUI and UUI.

AB - Aims: Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and without urinary incontinence (UI) and among subtypes of UI. Methods: Women with LUTS seeking care at six U.S. tertiary care centers enrolled in prospective cohort study were studied. At baseline, participants completed the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Organ Prolapse/Incontinence Sexual Questionnaire (PISQ-IR), and PROMIS GI Diarrhea, Constipation, and Fecal Incontinence Scales. Results: Mean age among the 510 women was 56.4 ± 14.4 years. Women who reported UI (n = 420) had more diarrhea and constipation symptoms (mean scores 49.5 vs 46.2 [P = 0.01] and 51.9 vs 48.4 [P < 0.01], respectively) at baseline. Among sexually active women, mean PISQ-IR subscale scores were lower among those with UI (condition specific: 89.8 vs 96.7, P < 0.01; condition impact: 79.8 vs 92.5, P < 0.01). Women with mixed urinary incontinence (MUI) (n = 240) reported more prolapse symptoms, fecal incontinence, and worse sexual function compared to those with stress urinary incontinence (SUI) and urgency urinary incontinence (UUI). Conclusions: Women presenting with LUTS with UI reported significantly worse constipation, diarrhea, fecal incontinence, and sexual function compared to women without UI. In women with UI, sexual function and pelvic organ prolapse (POP) symptoms were worse in those with MUI compared to SUI and UUI.

KW - constipation

KW - fecal incontinence

KW - pelvic organ prolapse

KW - urinary incontinence

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