BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Rimas V. Lukas; Ryan T. Merrell

doi:10.2217/cns-2017-0032

BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Rimas V. Lukas^*, Ryan T. Merrell

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.

Original language	English (US)
Article number	CNS10
Journal	CNS oncology
Volume	7
Issue number	2
DOIs	https://doi.org/10.2217/cns-2017-0032
State	Published - 2018

Keywords

BRAF
Optune
pleomorphic xanthoastrocytoma
tumor treating fields
vemurafenib

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.",

keywords = "BRAF, Optune, pleomorphic xanthoastrocytoma, tumor treating fields, vemurafenib",

author = "Lukas, {Rimas V.} and Merrell, {Ryan T.}",

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AU - Merrell, Ryan T.

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AB - Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.

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KW - pleomorphic xanthoastrocytoma

KW - tumor treating fields

KW - vemurafenib

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BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Abstract

Keywords

ASJC Scopus subject areas

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