BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Rimas V. Lukas, Ryan T. Merrell

Research output: Contribution to journalArticlepeer-review

Abstract

Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.

Original languageEnglish (US)
Pages (from-to)CNS10
JournalCNS oncology
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • BRAF
  • Optune
  • pleomorphic xanthoastrocytoma
  • tumor treating fields
  • vemurafenib

ASJC Scopus subject areas

  • Medicine(all)

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