Brain activation during anticipation of sound sequences

Amber M. Leaver, Jennifer Van Lare, Brandon Zielinski, Andrea R. Halpern, Josef P. Rauschecker

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Music consists of sound sequences that require integration over time. As we become familiar with music, associations between notes, melodies, and entire symphonic movements become stronger and more complex. These associations can become so tight that, for example, hearing the end of one album track can elicit a robust image of the upcoming track while anticipating it in total silence. Here, we study this predictive "anticipatory imagery" at various stages throughout learning and investigate activity changes in corresponding neural structures using functional magnetic resonance imaging. Anticipatory imagery (in silence) for highly familiar naturalistic music was accompanied by pronounced activity in rostral prefrontal cortex (PFC) and premotor areas. Examining changes in the neural bases of anticipatory imagery during two stages of learning conditional associations between simple melodies, however, demonstrates the importance of fronto-striatal connections, consistent with a role of the basal ganglia in "training" frontal cortex (Pasupathy and Miller, 2005). Another striking change in neural resources during learning was a shift between caudal PFC earlier to rostral PFC later in learning. Our findings regarding musical anticipation and sound sequence learning are highly compatible with studies of motor sequence learning, suggesting common predictive mechanisms in both domains.

Original languageEnglish (US)
Pages (from-to)2477-2485
Number of pages9
JournalJournal of Neuroscience
Volume29
Issue number8
DOIs
StatePublished - Feb 25 2009

Keywords

  • Auditory
  • Basal ganglia
  • FMRI
  • Learning and memory
  • Motor learning
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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