TY - JOUR
T1 - Brain computed tomography perfusion analysis in HIV-seropositive adults with and without neurocognitive impairment in Nigeria
T2 - outcomes and challenges of a pilot study
AU - Ogbole, Godwin
AU - Efidi, Richard
AU - Odo, Joseph
AU - Okorie, Chinonye
AU - Makanjuola, Tomiwa
AU - Adeyinka, Abiodun
AU - Sammet, Christina
AU - Berzins, Baiba
AU - Onoja, Akpa
AU - Ogunniyi, Adesola
AU - Ragin, Ann
AU - Taiwo, Babafemi
N1 - Publisher Copyright:
© Godwin Ogbole et al.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Introduction: the significance of cerebrovascular disease in HIV-associated neurocognitive disorder (HAND) in a homogeneous black population has not yet been determined. This incident case-control study used CT perfusion imaging to quantify and compare regional cerebral blood flow parameters in neuro-cognitively impaired and unimpaired HIV+ participants of the Ibadan Cohort on Neuro AIDS (ICON) in Nigeria. Methods: this was an incident case-control study consisting of twenty-seven HIV+ adults, classified based on Frascati criteria into neurocognitive impaired (n=18) and unimpaired (n=9) groups, who had brain computed tomographic perfusion (CTP) with a 64-slice Toshiba T scanner. The standard deviation (SD) of regional mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV) values were calculated for bilateral basal ganglia (BG), frontal, parietal, temporal, and occipital regions from CT perfusion maps. The regional mean values and variability (SD) in the CTP measures were compared in the groups using an independent student t-test. Results: differentially higher variability in the bilateral CBF measures in the parietal (right; OR = 1.14, x̅ =5.61, p=0.041, CI=0.27-11.35/left; OR = 1.16, x̅=7.01, p=0.03, CI=5.6-13.47) and time to peak (TTP) measures in the basal ganglia (right; OR = 3.78, x̅=0.88, p=0.032, CI=0.081-1.67/left; OR = 2.44, x̅=1.48, p=0.020, CI=0.26-2.71) and occipital (right; OR = 2.18, x̅=1.32, p=0.018, CI=0.25-2.38/left; OR = 1.93, x̅=1.08, p=0.034, CI=0.086-2.06) regions were observed in the cognitively impaired group compared to the unimpaired group. Conclusion: the study evidence suggests that alterations in cerebral perfusion implicated in HIV-associated neurocognitive disorder may be possibly demonstrated using CTP, a readily available resource in most African countries saddled with the highest burden of HIV.
AB - Introduction: the significance of cerebrovascular disease in HIV-associated neurocognitive disorder (HAND) in a homogeneous black population has not yet been determined. This incident case-control study used CT perfusion imaging to quantify and compare regional cerebral blood flow parameters in neuro-cognitively impaired and unimpaired HIV+ participants of the Ibadan Cohort on Neuro AIDS (ICON) in Nigeria. Methods: this was an incident case-control study consisting of twenty-seven HIV+ adults, classified based on Frascati criteria into neurocognitive impaired (n=18) and unimpaired (n=9) groups, who had brain computed tomographic perfusion (CTP) with a 64-slice Toshiba T scanner. The standard deviation (SD) of regional mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV) values were calculated for bilateral basal ganglia (BG), frontal, parietal, temporal, and occipital regions from CT perfusion maps. The regional mean values and variability (SD) in the CTP measures were compared in the groups using an independent student t-test. Results: differentially higher variability in the bilateral CBF measures in the parietal (right; OR = 1.14, x̅ =5.61, p=0.041, CI=0.27-11.35/left; OR = 1.16, x̅=7.01, p=0.03, CI=5.6-13.47) and time to peak (TTP) measures in the basal ganglia (right; OR = 3.78, x̅=0.88, p=0.032, CI=0.081-1.67/left; OR = 2.44, x̅=1.48, p=0.020, CI=0.26-2.71) and occipital (right; OR = 2.18, x̅=1.32, p=0.018, CI=0.25-2.38/left; OR = 1.93, x̅=1.08, p=0.034, CI=0.086-2.06) regions were observed in the cognitively impaired group compared to the unimpaired group. Conclusion: the study evidence suggests that alterations in cerebral perfusion implicated in HIV-associated neurocognitive disorder may be possibly demonstrated using CTP, a readily available resource in most African countries saddled with the highest burden of HIV.
KW - HIV
KW - HIV-associated neurocognitive disorder
KW - cerebrovascular
KW - computed tomography perfusion
KW - neuroAID
KW - neurocognitive
KW - neuroimaging
KW - people living with HIV
UR - http://www.scopus.com/inward/record.url?scp=85175170389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85175170389&partnerID=8YFLogxK
U2 - 10.11604/pamj.2023.46.15.36320
DO - 10.11604/pamj.2023.46.15.36320
M3 - Article
C2 - 38035155
AN - SCOPUS:85175170389
SN - 1937-8688
VL - 46
JO - Pan African Medical Journal
JF - Pan African Medical Journal
M1 - 15
ER -
