Brain enkephalin distribution is unaltered by hypophysectomy

Ronald M. Kobayashi; Miklos Palkovits; Richard J. Miller; Kwen Jen Chang; Pedro Cuatrecasas

doi:10.1016/0024-3205(78)90434-4

Brain enkephalin distribution is unaltered by hypophysectomy

Ronald M. Kobayashi^*, Miklos Palkovits, Richard J. Miller, Kwen Jen Chang, Pedro Cuatrecasas

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Methionine (met) and leucine (leu)-enkephalin were measured by radioimmunoassay in 16 brain regions removed by microdissection in intact rats. In hypophysectomized rats the regional concentrations of the enkephalins was not altered. Brain enkephalins do not appear to be derived from pituitary endorphins.

Original language	English (US)
Pages (from-to)	527-530
Number of pages	4
Journal	Life Sciences
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(78)90434-4
State	Published - Feb 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Brain enkephalin distribution is unaltered by hypophysectomy",

abstract = "Methionine (met) and leucine (leu)-enkephalin were measured by radioimmunoassay in 16 brain regions removed by microdissection in intact rats. In hypophysectomized rats the regional concentrations of the enkephalins was not altered. Brain enkephalins do not appear to be derived from pituitary endorphins.",

author = "Kobayashi, {Ronald M.} and Miklos Palkovits and Miller, {Richard J.} and Chang, {Kwen Jen} and Pedro Cuatrecasas",

note = "Funding Information: R .M .K . is recipient of a Clinical Investigator Award by the Veterans Administration and USPHS grant 26072 . We thank Patricia Kraus and Steven Painter for excellent technical assistance and Dea Pechnick for typing the manuscript .",

year = "1978",

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AU - Kobayashi, Ronald M.

AU - Palkovits, Miklos

AU - Miller, Richard J.

AU - Chang, Kwen Jen

AU - Cuatrecasas, Pedro

N1 - Funding Information: R .M .K . is recipient of a Clinical Investigator Award by the Veterans Administration and USPHS grant 26072 . We thank Patricia Kraus and Steven Painter for excellent technical assistance and Dea Pechnick for typing the manuscript .

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N2 - Methionine (met) and leucine (leu)-enkephalin were measured by radioimmunoassay in 16 brain regions removed by microdissection in intact rats. In hypophysectomized rats the regional concentrations of the enkephalins was not altered. Brain enkephalins do not appear to be derived from pituitary endorphins.

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Brain enkephalin distribution is unaltered by hypophysectomy

Abstract

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