Brain enkephalin distribution is unaltered by hypophysectomy

Ronald M. Kobayashi*, Miklos Palkovits, Richard J. Miller, Kwen Jen Chang, Pedro Cuatrecasas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Methionine (met) and leucine (leu)-enkephalin were measured by radioimmunoassay in 16 brain regions removed by microdissection in intact rats. In hypophysectomized rats the regional concentrations of the enkephalins was not altered. Brain enkephalins do not appear to be derived from pituitary endorphins.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
JournalLife Sciences
Issue number6
StatePublished - Feb 1978

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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