TY - JOUR
T1 - Brain Lesion Volume and Neuropsychological Function Predict Efficacy of Treatment for Depression in Multiple Sclerosis
AU - Mohr, David C.
AU - Epstein, Lucy
AU - Luks, Tracy L.
AU - Goodkin, Donald
AU - Cox, Darcy
AU - Goldberg, Alison
AU - Chin, Cynthia
AU - Nelson, Sarah
PY - 2003/12
Y1 - 2003/12
N2 - This study examined the effects of brain lesions and neuropsychological impairment on the efficacy of treatment for depression in patients with comorbid diagnoses of multiple sclerosis (MS) and major depressive disorder (MDD). Thirty patients meeting criteria for MS and MDD received 1 of 3 16-week treatments for depression and were followed for 6 months following treatment cessation. T2-weighted magnetic resonance imaging and neuropsychological evaluations were also obtained. End-of-treatment Beck Depression Inventory (BDI; A. T. Beck, C. H. Ward, M. Mendelson, J. Mock, & J. Erbaugh, 1961) results residualized for baseline BDI were related to right temporal periventricular lesion volume (R2 = .32, p = .002) and left temporal grey-white junction lesion volume (R2 = .19, p = .02) but were not statistically related to lesion volume in any other brain region or to neuropsychological function. BDI results at 6-month follow-up, residualized for end-of-treatment BDI, were predicted by total lesion volume (R2 = .22, p = .005), lesion volume in many discrete areas, and neuropsychological functioning (R2 = .29, p = .0009). The effect of total lesion volume on 6-month follow-up BDI results was fully mediated by neuropsychological function.
AB - This study examined the effects of brain lesions and neuropsychological impairment on the efficacy of treatment for depression in patients with comorbid diagnoses of multiple sclerosis (MS) and major depressive disorder (MDD). Thirty patients meeting criteria for MS and MDD received 1 of 3 16-week treatments for depression and were followed for 6 months following treatment cessation. T2-weighted magnetic resonance imaging and neuropsychological evaluations were also obtained. End-of-treatment Beck Depression Inventory (BDI; A. T. Beck, C. H. Ward, M. Mendelson, J. Mock, & J. Erbaugh, 1961) results residualized for baseline BDI were related to right temporal periventricular lesion volume (R2 = .32, p = .002) and left temporal grey-white junction lesion volume (R2 = .19, p = .02) but were not statistically related to lesion volume in any other brain region or to neuropsychological function. BDI results at 6-month follow-up, residualized for end-of-treatment BDI, were predicted by total lesion volume (R2 = .22, p = .005), lesion volume in many discrete areas, and neuropsychological functioning (R2 = .29, p = .0009). The effect of total lesion volume on 6-month follow-up BDI results was fully mediated by neuropsychological function.
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U2 - 10.1037/0022-006X.71.6.1017
DO - 10.1037/0022-006X.71.6.1017
M3 - Article
C2 - 14622077
AN - SCOPUS:0344064308
SN - 0022-006X
VL - 71
SP - 1017
EP - 1024
JO - Journal of Consulting and Clinical Psychology
JF - Journal of Consulting and Clinical Psychology
IS - 6
ER -