Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches

Rimas V. Lukas; Maciej S. Lesniak; Ravi Salgia

doi:10.2217/cns.13.66

Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches

Rimas V. Lukas, Maciej S. Lesniak, Ravi Salgia

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Non-small-cell lung cancer (NSCLC) patients experience a high incidence of brain metastases, de novo and recurrent. We review the mechanisms of brain metastases and promising NSCLC molecular markers to delineate potential future therapeutic targets. Discussed are the current and previously utilized roles of surgery, radiation (both therapeutic and prophylactic), and systemic therapies in the treatment of NSCLC brain metastases. Future directions for treatment of NSCLC brain metastases will conclude our review.

Original language	English (US)
Pages (from-to)	61-75
Number of pages	15
Journal	CNS oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.2217/cns.13.66
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2217/cns.13.66

Cite this

@article{23d96e0a225a430298569d2fa1db25ff,

title = "Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches",

abstract = "Non-small-cell lung cancer (NSCLC) patients experience a high incidence of brain metastases, de novo and recurrent. We review the mechanisms of brain metastases and promising NSCLC molecular markers to delineate potential future therapeutic targets. Discussed are the current and previously utilized roles of surgery, radiation (both therapeutic and prophylactic), and systemic therapies in the treatment of NSCLC brain metastases. Future directions for treatment of NSCLC brain metastases will conclude our review.",

author = "Lukas, {Rimas V.} and Lesniak, {Maciej S.} and Ravi Salgia",

note = "Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "2014",

month = jan,

day = "1",

doi = "10.2217/cns.13.66",

language = "English (US)",

volume = "3",

pages = "61--75",

journal = "CNS oncology",

issn = "2045-0915",

publisher = "Future Medicine Ltd.",

number = "1",

}

TY - JOUR

T1 - Brain metastases in non-small-cell lung cancer

T2 - better outcomes through current therapies and utilization of molecularly targeted approaches

AU - Lukas, Rimas V.

AU - Lesniak, Maciej S.

AU - Salgia, Ravi

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Non-small-cell lung cancer (NSCLC) patients experience a high incidence of brain metastases, de novo and recurrent. We review the mechanisms of brain metastases and promising NSCLC molecular markers to delineate potential future therapeutic targets. Discussed are the current and previously utilized roles of surgery, radiation (both therapeutic and prophylactic), and systemic therapies in the treatment of NSCLC brain metastases. Future directions for treatment of NSCLC brain metastases will conclude our review.

AB - Non-small-cell lung cancer (NSCLC) patients experience a high incidence of brain metastases, de novo and recurrent. We review the mechanisms of brain metastases and promising NSCLC molecular markers to delineate potential future therapeutic targets. Discussed are the current and previously utilized roles of surgery, radiation (both therapeutic and prophylactic), and systemic therapies in the treatment of NSCLC brain metastases. Future directions for treatment of NSCLC brain metastases will conclude our review.

UR - http://www.scopus.com/inward/record.url?scp=84924737900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924737900&partnerID=8YFLogxK

U2 - 10.2217/cns.13.66

DO - 10.2217/cns.13.66

M3 - Review article

C2 - 25054901

AN - SCOPUS:84924737900

SN - 2045-0915

VL - 3

SP - 61

EP - 75

JO - CNS oncology

JF - CNS oncology

IS - 1

ER -

Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this