Brain MR spectroscopic findings in 3 consecutive patients with covid-19: Preliminary observations

O. Rapalino*, A. Weerasekera, S. J. Moum, K. Eikermann-Haerter, B. L. Edlow, D. Fischer, A. Torrado-Carvajal, M. L. Loggia, S. S. Mukerji, P. W. Schaefer, R. G. Gonzalez, M. H. Lev, E. M. Ratai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number1
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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