Abstract
Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-41 |
| Number of pages | 5 |
| Journal | American Journal of Neuroradiology |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2021 |
Funding
Received June 14, 2020; accepted after revision August 13. From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.) and Neurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; A.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts; Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine (S.J.M.) and Medical Image Analysis and Biometry Laboratory (A.T.-C.), Universidad Rey Juan Carlos, Madrid, Spain. O. Rapalino and A. Weerasekera contributed equally to this article. M.L. Loggia was funded by the National Institutes of Health grant 1R01NS095937-01A1. Disclosures: Otto Rapalino—UNRELATED: Travel and hotel expenses as a lecturer at an event were sponsored by GE Healthcare in August 2019. This lecture did not have any commercial content and did not have any relationship to the current work. Brian L. Edlow—RELATED: Grant: James S. McDonnell Foundation, Comments: McDonnell Foundation COVID-19 Recovery of Consciousness Consortium.* David Fischer— RELATED: Grant: R25NS06574309. Shibani Mukerji—UNRELATED: Grants/Grants Pending: National Institute of Mental Health, Comments: K23MH115812.* Michael H. Lev —UNRELATED: Consultancy: Takeda Pharmaceutical Company, GE Healthcare, Comments: Consultant; Grants/Grants Pending: National Institutes of Health, Comments: Coinvestigator on 2 technical development grants; Patents (Planned, Pending or Issued): Electrical Impedance Spectroscopy, Artificial Intelligence-related. Eva-Maria Ratai—UNRELATED: Employment: Massachusetts General Hospital; Grants/ Grants Pending: National Institutes of Health, National Science Foundation, Comments: R01NS080816, R01HD065762, R01HD085813, U01NS104326, R01DA047088, P01-AT009965, R01CA190901, R01NS112694.* Marco L. Loggia—RELATED: Grant: National Institute of Neurological Disorders and Stroke, Comments: 1R01NS095937-01A1*; UNRELATED: Grants/Grants Pending: National Institutes of Health. Angel Torrado-Carvajal— UNRELATED: Employment: Universidad Rey Juan Carlos, Assistant Professor (September 2019 until now); Massachusetts General Hospital, Research Fellow (August 2017 to August 2019); Grants/Grants Pending: Comunidad de Madrid, MIMC3 PET/MR Project.* *Money paid to the institution.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology