Brain pyruvate dehydrogenase activity: regulation by phosphorylation-dephosphorylation

David G. Morgan; Aryeh Routtenberg

doi:10.1016/0006-8993(82)90761-2

Brain pyruvate dehydrogenase activity: regulation by phosphorylation-dephosphorylation

David G. Morgan, Aryeh Routtenberg^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The alpha-subunit of pyruvate dehydrogenase (PDHa) decarboxylates pyruvate and is the rate-limiting step in the PDH-complex reaction sequence. Using different phosphorylation conditions which inhibit PDHa-kinase of PDHa-phosphatase, we demonstrate that PDHa in brain is regulated by a phosphorylation (inactivation) - dephosphorylation (activation) cycle.

Original language	English (US)
Pages (from-to)	391-394
Number of pages	4
Journal	Brain research
Volume	251
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)90761-2
State	Published - Nov 18 1982

Keywords

brain protein phosphorylation
dephosphorylation cycles
gel electrophoresis
phosphorylation
pyruvate dehydrogenase

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Brain pyruvate dehydrogenase activity: regulation by phosphorylation-dephosphorylation",

abstract = "The alpha-subunit of pyruvate dehydrogenase (PDHa) decarboxylates pyruvate and is the rate-limiting step in the PDH-complex reaction sequence. Using different phosphorylation conditions which inhibit PDHa-kinase of PDHa-phosphatase, we demonstrate that PDHa in brain is regulated by a phosphorylation (inactivation) - dephosphorylation (activation) cycle.",

keywords = "brain protein phosphorylation, dephosphorylation cycles, gel electrophoresis, phosphorylation, pyruvate dehydrogenase",

author = "Morgan, {David G.} and Aryeh Routtenberg",

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T1 - Brain pyruvate dehydrogenase activity

T2 - regulation by phosphorylation-dephosphorylation

AU - Morgan, David G.

AU - Routtenberg, Aryeh

PY - 1982/11/18

Y1 - 1982/11/18

N2 - The alpha-subunit of pyruvate dehydrogenase (PDHa) decarboxylates pyruvate and is the rate-limiting step in the PDH-complex reaction sequence. Using different phosphorylation conditions which inhibit PDHa-kinase of PDHa-phosphatase, we demonstrate that PDHa in brain is regulated by a phosphorylation (inactivation) - dephosphorylation (activation) cycle.

AB - The alpha-subunit of pyruvate dehydrogenase (PDHa) decarboxylates pyruvate and is the rate-limiting step in the PDH-complex reaction sequence. Using different phosphorylation conditions which inhibit PDHa-kinase of PDHa-phosphatase, we demonstrate that PDHa in brain is regulated by a phosphorylation (inactivation) - dephosphorylation (activation) cycle.

KW - brain protein phosphorylation

KW - dephosphorylation cycles

KW - gel electrophoresis

KW - phosphorylation

KW - pyruvate dehydrogenase

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EP - 394

JO - Brain research

JF - Brain research

IS - 2

ER -

Brain pyruvate dehydrogenase activity: regulation by phosphorylation-dephosphorylation

Abstract

Keywords

ASJC Scopus subject areas

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