Brain pyruvate dehydrogenase activity: regulation by phosphorylation-dephosphorylation

David G. Morgan, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The alpha-subunit of pyruvate dehydrogenase (PDHa) decarboxylates pyruvate and is the rate-limiting step in the PDH-complex reaction sequence. Using different phosphorylation conditions which inhibit PDHa-kinase of PDHa-phosphatase, we demonstrate that PDHa in brain is regulated by a phosphorylation (inactivation) - dephosphorylation (activation) cycle.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalBrain research
Volume251
Issue number2
DOIs
StatePublished - Nov 18 1982

Keywords

  • brain protein phosphorylation
  • dephosphorylation cycles
  • gel electrophoresis
  • phosphorylation
  • pyruvate dehydrogenase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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