Brain pyruvate dehydrogenase: Phosphorylation and enzyme activity altered by a training experience

David G. Morgan, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The active portion of the alpha subunit of pyruvate dehydrogenase in rat frontal cortex was elevated after a training experience. No change in total pyruvate dehydrogenase activity was observed. The phosphorylation in vitro of pyruvate dehydrogenase (band F-2) was also elevated after training. Since activation of pyruvate dehydrogenase requires its dephosphorylation, the following sequence is proposed. Training alters frontal cortex activity and reduces the phosphate content of pyruvate dehydrogenase in vivo; this leads to enzyme activation and an increase in back-titration of sites available for phosphorylation in vitro.

Original languageEnglish (US)
Pages (from-to)470-471
Number of pages2
JournalScience
Volume214
Issue number4519
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • General

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