Brain tissue oxygen regulation in awake and anesthetized neonates

Daniil P. Aksenov*, Andrey V. Dmitriev, Michael J. Miller, Alice M. Wyrwicz, Robert A Linsenmeier

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Inhaled general anesthetics are used commonly in adults and children, and a growing body of literature from animals and humans suggests that exposure to anesthesia at an early age can impact brain development. While the origin of these effects is not well understood, it is known that anesthesia can disrupt oxygen regulation in the brain, which is critically important for maintaining healthy brain function. Here we investigated how anesthesia affected brain tissue oxygen regulation in neonatal rabbits by comparing brain tissue oxygen and single unit activity in the awake and anesthetized states. We tested two common general anesthetics, isoflurane and sevoflurane, delivered in both air and 80% oxygen. Our findings show that general anesthetics can greatly increase brain tissue PO 2 in neonates, especially when combined with supplemental oxygen. Although isoflurane and sevoflurane belong to the same class of anesthetics, notable differences were observed in their effects upon neuronal activity and spontaneous respiration. Our findings point to the need to consider the potential effects of hyperoxia when supplemental oxygen is utilized, particularly in children and neonates.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalNeuropharmacology
Volume135
DOIs
StatePublished - Jun 1 2018

Fingerprint

Newborn Infant
Oxygen
General Anesthetics
Brain
Anesthesia
Isoflurane
Hyperoxia
Anesthetics
Respiration
Air
Rabbits
sevoflurane

Keywords

  • Electrophysiology
  • Isoflurane
  • Rabbit
  • Sevoflurane
  • Single unit

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Aksenov, Daniil P. ; Dmitriev, Andrey V. ; Miller, Michael J. ; Wyrwicz, Alice M. ; Linsenmeier, Robert A. / Brain tissue oxygen regulation in awake and anesthetized neonates. In: Neuropharmacology. 2018 ; Vol. 135. pp. 368-375.
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Brain tissue oxygen regulation in awake and anesthetized neonates. / Aksenov, Daniil P.; Dmitriev, Andrey V.; Miller, Michael J.; Wyrwicz, Alice M.; Linsenmeier, Robert A.

In: Neuropharmacology, Vol. 135, 01.06.2018, p. 368-375.

Research output: Contribution to journalArticle

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AU - Linsenmeier, Robert A

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