TY - JOUR
T1 - Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
AU - Karbasforoushan, Haleh
AU - Cohen-Adad, Julien
AU - Dewald, Julius P.A.
N1 - Funding Information:
We are indebted to the individuals with stroke who participated in this study. We thank Azmi Banibaker, ARRT, for his assistance with MRI data collection, and Kevin Wilkins for his insightful comments on statistical analyses. This research was supported by funding from the NIH R01HD039343 and R01NS105759 awarded to J.P.A.D. and NIH NRSA F31NS105486 awarded to H.K.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
AB - Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
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U2 - 10.1038/s41467-019-11244-3
DO - 10.1038/s41467-019-11244-3
M3 - Article
C2 - 31388003
AN - SCOPUS:85070299128
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 3524
ER -