Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue

Jason R. Fangusaro*, Rima F. Jubran, Jeffrey Allen, Sharon Gardner, Ira J. Dunkel, Mark Rosenblum, Mark P. Atlas, Ignacio Gonzalez-Gomez, Douglas Miller, Jonathan L. Finlay

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We have evaluated the response rate and survival utilizing intensified chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) and adjuvant radiation therapy in six young children with newly diagnosed brainstem primitive neuroectodermal tumors (bstPNET). Following maximum surgical resection of the tumor, patients received high dose induction chemotherapy including vincristine, cisplatin, cyclophosphamide, and etoposide. Eligible patients received a single cycle of myeloablative chemotherapy followed by AuHCR. Two patients survive at least 32 months with stable disease. This approach provides an alternative for young patients with bstPNET who in prior reports have had a uniformly fatal prognosis.

Original languageEnglish (US)
Pages (from-to)715-717
Number of pages3
JournalPediatric Blood and Cancer
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Autologous transplant
  • Brainstem
  • Chemotherapy
  • Primitive neuroectodermal tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue'. Together they form a unique fingerprint.

  • Cite this

    Fangusaro, J. R., Jubran, R. F., Allen, J., Gardner, S., Dunkel, I. J., Rosenblum, M., Atlas, M. P., Gonzalez-Gomez, I., Miller, D., & Finlay, J. L. (2008). Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue. Pediatric Blood and Cancer, 50(3), 715-717. https://doi.org/10.1002/pbc.21032