Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park; Soojeong Cho; Xiaoke Huang; Andrew C. Larson; Dong Hyun Kim

doi:10.1002/smll.201602722

Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park, Soojeong Cho, Xiaoke Huang, Andrew C. Larson^*, Dong Hyun Kim

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.

Original language	English (US)
Article number	1602722
Journal	Small
Volume	13
Issue number	5
DOIs	https://doi.org/10.1002/smll.201602722
State	Published - Jan 1 2017

Keywords

Clostridium novyi-NT
bacteriolytic tumor therapy
computed tomography image-guided therapy
gold nanoparticles

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

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10.1002/smll.201602722

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Park, W., Cho, S., Huang, X., Larson, A. C., & Kim, D. H. (2017). Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection. Small, 13(5), [1602722]. https://doi.org/10.1002/smll.201602722

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abstract = "A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.",

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