Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park; Soojeong Cho; Xiaoke Huang; Andrew C. Larson; Dong Hyun Kim

doi:10.1002/smll.201602722

Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park, Soojeong Cho, Xiaoke Huang, Andrew C. Larson^*, Dong Hyun Kim

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.

Original language	English (US)
Article number	1602722
Journal	Small
Volume	13
Issue number	5
DOIs	https://doi.org/10.1002/smll.201602722
State	Published - 2017

Keywords

Clostridium novyi-NT
bacteriolytic tumor therapy
computed tomography image-guided therapy
gold nanoparticles

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

Access to Document

10.1002/smll.201602722

Fingerprint Dive into the research topics of 'Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection'. Together they form a unique fingerprint.

Cite this

@article{6909bf4f119b4850a9f68910a0ae11d3,

title = "Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection",

abstract = "A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.",

keywords = "Clostridium novyi-NT, bacteriolytic tumor therapy, computed tomography image-guided therapy, gold nanoparticles",

author = "Wooram Park and Soojeong Cho and Xiaoke Huang and Larson, {Andrew C.} and Kim, {Dong Hyun}",

note = "Funding Information: The financial support from NIH/NCI-R01CA159178 (A.C.L.), R21CA173491 (D.-H.K.), and R21CA185274 (D.-H.K), and NIH/NIBIB-R21EB017986 (D.-H.K.) are greatly acknowledged. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University. Animal experiments were performed in accordance with protocols approved by Institutional Animal Care and Use Committee (IACUC) of Northwestern University.",

year = "2017",

doi = "10.1002/smll.201602722",

language = "English (US)",

volume = "13",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "5",

}

TY - JOUR

T1 - Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

AU - Park, Wooram

AU - Cho, Soojeong

AU - Huang, Xiaoke

AU - Larson, Andrew C.

AU - Kim, Dong Hyun

N1 - Funding Information: The financial support from NIH/NCI-R01CA159178 (A.C.L.), R21CA173491 (D.-H.K.), and R21CA185274 (D.-H.K), and NIH/NIBIB-R21EB017986 (D.-H.K.) are greatly acknowledged. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University. Animal experiments were performed in accordance with protocols approved by Institutional Animal Care and Use Committee (IACUC) of Northwestern University.

PY - 2017

Y1 - 2017

N2 - A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.

AB - A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.

KW - Clostridium novyi-NT

KW - bacteriolytic tumor therapy

KW - computed tomography image-guided therapy

KW - gold nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85005980378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005980378&partnerID=8YFLogxK

U2 - 10.1002/smll.201602722

DO - 10.1002/smll.201602722

M3 - Article

C2 - 27862936

AN - SCOPUS:85005980378

VL - 13

JO - Small

JF - Small

SN - 1613-6810

IS - 5

M1 - 1602722

ER -