Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park, Soojeong Cho, Xiaoke Huang, Andrew C. Larson*, Dong Hyun Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.

Original languageEnglish (US)
Article number1602722
JournalSmall
Volume13
Issue number5
DOIs
StatePublished - Jan 1 2017

Keywords

  • Clostridium novyi-NT
  • bacteriolytic tumor therapy
  • computed tomography image-guided therapy
  • gold nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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