Abstract
A new type of branched gold nanoparticles (BGNP)-coated C. novyi-NT spore was demonstrated for efficient CT-image guided bacteriolytic tumor therapy. BGNP-coated C. novyi-NT spores were successfully prepared with electrostatic deposition methods. In a PC3 human prostate tumor xenograft mouse model, the BGNP-coated spores were injected into a tumor site under CT image guidance. The infused BGNP-coated spores exhibited strong therapeutic efficacy consistent with that observed for native C. novyi-NT spores suggesting that the innate antitumoral function was preserved. Based on these results, it is believed that our BGNP-coated C. novyi-NT spores have the potential to not only facilitate CT image-guided bacteriolytic procedures but also to serve as a novel delivery platform for a combinational tumor therapy.
Original language | English (US) |
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Article number | 1602722 |
Journal | Small |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - 2017 |
Keywords
- Clostridium novyi-NT
- bacteriolytic tumor therapy
- computed tomography image-guided therapy
- gold nanoparticles
ASJC Scopus subject areas
- Biotechnology
- Biomaterials
- Chemistry(all)
- Materials Science(all)