Abstract
Anaplasma phagocytophilum invades neutrophils to cause the emerging infection, human granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum invasin-host cell receptor interactions that promote bacterial entry and the degradative and membrane traffic pathways that the organism exploits to route nutrients to the organelle in which it resides. Because its obligatory intracellular nature hinders knock out-complementation approaches, we also discuss the current methods used to study A. phagocytophilum gene function and the potential benefit of applying novel tools that have advanced studies of other obligate intracellular bacterial pathogens.
Original language | English (US) |
---|---|
Pages (from-to) | 1017-1025 |
Number of pages | 9 |
Journal | Microbes and Infection |
Volume | 15 |
Issue number | 14-15 |
DOIs | |
State | Published - Dec 2013 |
Externally published | Yes |
Keywords
- Bacterial invasion
- Ehrlichia
- Nutritional virulence
- Obligate intracellular
- Rab GTPase
- Rickettsia
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases