Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular invasion, nutrient acquisition, and promising tools for their study

Hilary K. Truchan, David Seidman, Jason A. Carlyon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Anaplasma phagocytophilum invades neutrophils to cause the emerging infection, human granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum invasin-host cell receptor interactions that promote bacterial entry and the degradative and membrane traffic pathways that the organism exploits to route nutrients to the organelle in which it resides. Because its obligatory intracellular nature hinders knock out-complementation approaches, we also discuss the current methods used to study A. phagocytophilum gene function and the potential benefit of applying novel tools that have advanced studies of other obligate intracellular bacterial pathogens.

Original languageEnglish (US)
Pages (from-to)1017-1025
Number of pages9
JournalMicrobes and Infection
Volume15
Issue number14-15
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Bacterial invasion
  • Ehrlichia
  • Nutritional virulence
  • Obligate intracellular
  • Rab GTPase
  • Rickettsia

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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