Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Ashleigh J. Jackobel, Yan Han, Yuan He, Bruce A. Knutson*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations

Abstract

While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalTranscription
Volume9
Issue number4
DOIs
StatePublished - Aug 8 2018

Keywords

  • Core Factor
  • RNA polymerase I
  • pre-initiation complex
  • promoter opening
  • promoter recognition
  • transcription initiation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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