Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Ashleigh J. Jackobel; Yan Han; Yuan He; Bruce A. Knutson

doi:10.1080/21541264.2017.1416268

Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Ashleigh J. Jackobel, Yan Han, Yuan He, Bruce A. Knutson^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.

Original language	English (US)
Pages (from-to)	255-261
Number of pages	7
Journal	Transcription
Volume	9
Issue number	4
DOIs	https://doi.org/10.1080/21541264.2017.1416268
State	Published - Aug 8 2018

Funding

This work was supported by a Cornew Innovation Award from the Chemistry of Life Processes Institute at Northwestern University (to Y. He), a Catalyst Award by the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust (to Y. He), an Institutional Research Grant from the American Cancer Society (IRG-15-173-21 to Y. He), SUNY Research Foundation (to BAK), the Central New York Community Foundation (to BAK), Joseph C. George Fund, and Virginia Simons & Dr. C. Adele Brown Fund (to BAK), the Carol M. Baldwin Breast Cancer Fund (to BAK), and the US National Institutes of Health (NCI 5K22CA184235 to BAK). BAK is a Sinsheimer Scholar. Y. Han is a recipient of the Chicago Biomedical Consortium Postdoctoral Research Grant. We apologize for those whose work was not cited due to space limitations. This work was supported by a Cornew Innovation Award from the Chemistry of Life Processes Institute at Northwestern University (to Y. He), a Catalyst Award by the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust (to Y. He), an Institutional Research Grant from the American Cancer Society (IRG-15-173-21 to Y. He), SUNY Research Foundation (to BAK), the Central New York Community Foundation (to BAK), Joseph C. George Fund, and Virginia Simons & Dr. C. Adele Brown Fund (to BAK), the Carol M. Baldwin Breast Cancer Fund (to BAK), and the US National Institutes of Health (NCI 5K22CA184235 to BAK). BAK is a Sinsheimer Scholar.

Keywords

Core Factor
RNA polymerase I
pre-initiation complex
promoter opening
promoter recognition
transcription initiation

ASJC Scopus subject areas

Genetics
Biochemistry
Biotechnology

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10.1080/21541264.2017.1416268

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abstract = "While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.",

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AU - Han, Yan

AU - He, Yuan

AU - Knutson, Bruce A.

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Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

Abstract

Funding

Keywords

ASJC Scopus subject areas

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