Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Mirna Chehade; Benjamin L. Wright; Dan Atkins; Seema S. Aceves; Steven J. Ackerman; Amal H. Assa'ad; Maureen Bauer; Margaret H. Collins; Scott P. Commins; Carla M. Davis; Evan S. Dellon; Bethan Doerfler; Gerald J. Gleich; Sandeep K. Gupta; David A. Hill; Elizabeth T. Jensen; David Katzka; Kara Kliewer; Ellyn Kodroff; Leah C. Kottyan; Shay Kyle; Amanda B. Muir; Robert D. Pesek; Kathryn Peterson; Wayne G. Shreffler; Jonathan M. Spergel; Mary Jo Strobel; Joshua Wechsler; Nives Zimmermann; Glenn T. Furuta; Marc E. Rothenberg

doi:10.1016/j.jaci.2023.08.021

Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Mirna Chehade^*, Benjamin L. Wright, Dan Atkins, Seema S. Aceves, Steven J. Ackerman, Amal H. Assa'ad, Maureen Bauer, Margaret H. Collins, Scott P. Commins, Carla M. Davis, Evan S. Dellon, Bethan Doerfler, Gerald J. Gleich, Sandeep K. Gupta, David A. Hill, Elizabeth T. Jensen, David Katzka, Kara Kliewer, Ellyn Kodroff, Leah C. KottyanShay Kyle, Amanda B. Muir, Robert D. Pesek, Kathryn Peterson, Wayne G. Shreffler, Jonathan M. Spergel, Mary Jo Strobel, Joshua Wechsler, Nives Zimmermann, Glenn T. Furuta, Marc E. Rothenberg

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The Consortium of Eosinophilic Gastrointestinal Diseases and The International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition to advances in our understanding of the clinical features of EGIDs. Diagnostic and management approaches were reviewed and debated, and clinical trials of emerging therapies were highlighted. Herein, we briefly summarize the breakthrough discoveries in EGIDs.

Original language	English (US)
Pages (from-to)	1382-1393
Number of pages	12
Journal	Journal of Allergy and Clinical Immunology
Volume	152
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2023.08.021
State	Published - Dec 2023

Funding

We also thank the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) (U54AI117804), which is part of the Rare Disease Clinical Research Network (RDCRN), an initiative of the Office of Rare Diseases Research (ORDR), NCATS, and funded through collaboration between NIAID, NIDDK, and NCATS. CEGIR is also supported by patient advocacy groups including American Partnership for Eosinophilic Disorders (APFED), Campaign Urging Research for Eosinophilic Diseases (CURED), and Eosinophilic Family Coalition (EFC). As a member of the RDCRN, CEGIR is also supported by its Data Management and Coordinating Center (DMCC) (U2CTR002818). Funding support for the DMCC is provided by the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Neurological Disorders and Stroke (NINDS).

Keywords

Eosinophilic esophagitis
eosinophil
eosinophilic gastritis
food allergy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaci.2023.08.021

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Chehade, M., Wright, B. L., Atkins, D., Aceves, S. S., Ackerman, S. J., Assa'ad, A. H., Bauer, M., Collins, M. H., Commins, S. P., Davis, C. M., Dellon, E. S., Doerfler, B., Gleich, G. J., Gupta, S. K., Hill, D. A., Jensen, E. T., Katzka, D., Kliewer, K., Kodroff, E., ... Rothenberg, M. E. (2023). Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting. Journal of Allergy and Clinical Immunology, 152(6), 1382-1393. https://doi.org/10.1016/j.jaci.2023.08.021

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title = "Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting",

abstract = "The Consortium of Eosinophilic Gastrointestinal Diseases and The International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition to advances in our understanding of the clinical features of EGIDs. Diagnostic and management approaches were reviewed and debated, and clinical trials of emerging therapies were highlighted. Herein, we briefly summarize the breakthrough discoveries in EGIDs.",

keywords = "Eosinophilic esophagitis, eosinophil, eosinophilic gastritis, food allergy",

author = "Mirna Chehade and Wright, {Benjamin L.} and Dan Atkins and Aceves, {Seema S.} and Ackerman, {Steven J.} and Assa'ad, {Amal H.} and Maureen Bauer and Collins, {Margaret H.} and Commins, {Scott P.} and Davis, {Carla M.} and Dellon, {Evan S.} and Bethan Doerfler and Gleich, {Gerald J.} and Gupta, {Sandeep K.} and Hill, {David A.} and Jensen, {Elizabeth T.} and David Katzka and Kara Kliewer and Ellyn Kodroff and Kottyan, {Leah C.} and Shay Kyle and Muir, {Amanda B.} and Pesek, {Robert D.} and Kathryn Peterson and Shreffler, {Wayne G.} and Spergel, {Jonathan M.} and Strobel, {Mary Jo} and Joshua Wechsler and Nives Zimmermann and Furuta, {Glenn T.} and Rothenberg, {Marc E.}",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Allergy, Asthma & Immunology",

year = "2023",

month = dec,

doi = "10.1016/j.jaci.2023.08.021",

language = "English (US)",

volume = "152",

pages = "1382--1393",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

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number = "6",

}

Chehade, M, Wright, BL, Atkins, D, Aceves, SS, Ackerman, SJ, Assa'ad, AH, Bauer, M, Collins, MH, Commins, SP, Davis, CM, Dellon, ES, Doerfler, B, Gleich, GJ, Gupta, SK, Hill, DA, Jensen, ET, Katzka, D, Kliewer, K, Kodroff, E, Kottyan, LC, Kyle, S, Muir, AB, Pesek, RD, Peterson, K, Shreffler, WG, Spergel, JM, Strobel, MJ, Wechsler, J, Zimmermann, N, Furuta, GT & Rothenberg, ME 2023, 'Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting', Journal of Allergy and Clinical Immunology, vol. 152, no. 6, pp. 1382-1393. https://doi.org/10.1016/j.jaci.2023.08.021

Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting. / Chehade, Mirna; Wright, Benjamin L.; Atkins, Dan et al.
In: Journal of Allergy and Clinical Immunology, Vol. 152, No. 6, 12.2023, p. 1382-1393.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

AU - Chehade, Mirna

AU - Wright, Benjamin L.

AU - Atkins, Dan

AU - Aceves, Seema S.

AU - Ackerman, Steven J.

AU - Assa'ad, Amal H.

AU - Bauer, Maureen

AU - Collins, Margaret H.

AU - Commins, Scott P.

AU - Davis, Carla M.

AU - Dellon, Evan S.

AU - Doerfler, Bethan

AU - Gleich, Gerald J.

AU - Gupta, Sandeep K.

AU - Hill, David A.

AU - Jensen, Elizabeth T.

AU - Katzka, David

AU - Kliewer, Kara

AU - Kodroff, Ellyn

AU - Kottyan, Leah C.

AU - Kyle, Shay

AU - Muir, Amanda B.

AU - Pesek, Robert D.

AU - Peterson, Kathryn

AU - Shreffler, Wayne G.

AU - Spergel, Jonathan M.

AU - Strobel, Mary Jo

AU - Wechsler, Joshua

AU - Zimmermann, Nives

AU - Furuta, Glenn T.

AU - Rothenberg, Marc E.

PY - 2023/12

Y1 - 2023/12

N2 - The Consortium of Eosinophilic Gastrointestinal Diseases and The International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition to advances in our understanding of the clinical features of EGIDs. Diagnostic and management approaches were reviewed and debated, and clinical trials of emerging therapies were highlighted. Herein, we briefly summarize the breakthrough discoveries in EGIDs.

AB - The Consortium of Eosinophilic Gastrointestinal Diseases and The International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition to advances in our understanding of the clinical features of EGIDs. Diagnostic and management approaches were reviewed and debated, and clinical trials of emerging therapies were highlighted. Herein, we briefly summarize the breakthrough discoveries in EGIDs.

KW - Eosinophilic esophagitis

KW - eosinophil

KW - eosinophilic gastritis

KW - food allergy

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U2 - 10.1016/j.jaci.2023.08.021

DO - 10.1016/j.jaci.2023.08.021

M3 - Review article

C2 - 37660987

AN - SCOPUS:85172016382

SN - 0091-6749

VL - 152

SP - 1382

EP - 1393

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 6

ER -

Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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