Breastfeeding, maternal asthma and wheezing in the first year of life: A longitudinal birth cohort study

Meghan B. Azad*, Lorena Vehling, Zihang Lu, David Dai, Padmaja Subbarao, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Diana L. Lefebvre, Malcolm R. Sears, S. S. Anand, A. D. Befus, M. Brauer, J. R. Brook, E. Chen, M. Cyr, D. Daley, S. Dell, J. A. Denburg, Q. DuanT. Eiwegger, H. Grasemann, K. HayGlass, R. Hegele, D. L. Holness, P. Hystad, W. Y.W. Lou, M. S. Kobor, T. R. Kollman, A. L. Kozyrskyj, C. Laprise, J. Macri, P. M. Mandhane, G. Miller, T. Moraes, P. D. Paré, C. Ramsey, F. Ratjen, A. Sandford, J. A. Scott, J. Scott, F. Silverman, E. Simons, T. Takaro, S. Tebbutt, T. To

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life. We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none. Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35 - 0.77 for ≥12 versus < 6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20 - 0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43 - 0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61 - 1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction < 0.01). Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

Original languageEnglish (US)
Article number1602019
JournalEuropean Respiratory Journal
Volume49
Issue number5
DOIs
StatePublished - May 1 2017

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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