@article{b9f14288d6f94f59aea0dd69827a2e51,
title = "Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection",
abstract = "To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.",
keywords = "APRI, HBV, HCV, HIV, antiviral therapy, hepatitis, liver",
author = "Price, {Jennifer C.} and Seaberg, {Eric C.} and Phair, {John P.} and Witt, {Mallory D.} and Koletar, {Susan L.} and Thio, {Chloe L.}",
note = "Funding Information: This work was funded by the National Center for Research Resources (1KL2RR025006-01 to J.C.P.) and the National Institute on Drug Abuse (NIDA) (5R03DA026094-02 to C.L.T.). Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS). MACS (Principal Investigators): Johns Hopkins University Bloomberg School of Public Health (Joseph Margolick), U01-AI35042; Northwestern University (Steven Wolinsky), U01-AI35039; University of California, Los Angeles (Roger Detels), U01-AI35040; University of Pittsburgh (Charles Rinaldo), U01-AI35041; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (Lisa Jacobson), UM1-AI35043. The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases with additional cofunding from the National Cancer Institute, NIDA, and the National Institute of Mental Health. Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute, and the National Institute on Deafness and Communication Disorders. MACS data collection is also supported by UL1-TR001079 (JHU ICTR) from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research and the Los Angeles Biomedical Research Institute at Harbor-UCLA CTSI, UL1TR000124. J.C.P. has received Grant support from Gilead Sciences. C.L.T. has received Grant support from Gilead Sciences. The remaining authors have no funding or conflicts of interest to disclose. Publisher Copyright: {\textcopyright} Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2016",
month = jul,
day = "1",
doi = "10.1097/QAI.0000000000000981",
language = "English (US)",
volume = "72",
pages = "319--323",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}
