Brushite stone disease as a consequence of lithotripsy?

Amy E. Krambeck, Shelly E. Handa, Andrew P. Evan, James E. Lingeman

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The incidence of calcium phosphate (CaP) stone disease has increased over the last three decades; specifically, brushite stones have been diagnosed and treated more frequently than in previous years. Brushite is a unique form of CaP, which in certain patients can form into large symptomatic stones. Treatment of brushite stones can be difficult since the stones are resistant to shock wave and ultrasonic lithotripsy, and often require ballistic fragmentation. Patients suffering from brushite stone disease are less likely to be rendered stone free after surgical intervention and often experience stone recurrence despite maximal medical intervention. Studies have demonstrated an association between brushite stone disease and shock wave lithotripsy (SWL) treatment. Some have theorized that many brushite stone formers started as routine calcium oxalate (CaOx) stone formers who sustained an injury to the nephron (such as SWL). The injury to the nephron leads to failure of urine acidification and eventual brushite stone formation. We explore the association between brushite stone disease and iatrogenic transformation of CaOx stone disease to brushite by reviewing the current literature.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalUrological Research
Issue number4
StatePublished - Aug 2010
Externally publishedYes


  • Brushite
  • Calcium phosphate
  • Randall's plaque
  • Shock wave lithotripsy

ASJC Scopus subject areas

  • Urology

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