TY - JOUR
T1 - Building Organs Using Tissue-Specific Microenvironments
T2 - Perspectives from a Bioprosthetic Ovary
AU - Henning, Nathaniel F.C.
AU - Jakus, Adam E.
AU - Laronda, Monica M.
N1 - Funding Information:
This work was supported in part by the Stanley Manne Children’s Research Institute and the Ann and Robert H. Lurie Children’s Hospital of Chicago (to N.F.C.H.), the Warren and Eloise Batts endowment (M.M.L.), and a Burroughs Wellcome Fund Career Award at the Scientific Interface (1014568, M.M.L.).
Funding Information:
This work was supported in part by the Stanley Manne Children's Research Institute and the Ann and Robert H. Lurie Children's Hospital of Chicago (to N.F.C.H.), the Warren and Eloise Batts endowment (M.M.L.), and a Burroughs Wellcome Fund Career Award at the Scientific Interface (1014568, M.M.L.). A.J. is a co-founder and CTO of the company, Dimension Inx. and has ownership and other financial interests in this company. Dimension Inx. did not influence the contents of this article. The other authors declare no conflicts of interest.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications.
AB - Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications.
KW - bioengineering
KW - matrisome
KW - ovary
KW - regenerative medicine
KW - tissue engineering
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U2 - 10.1016/j.tibtech.2021.01.008
DO - 10.1016/j.tibtech.2021.01.008
M3 - Review article
C2 - 33593603
AN - SCOPUS:85101007745
SN - 0167-7799
VL - 39
SP - 824
EP - 837
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 8
ER -