Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb

Adam Wood, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

48 Scopus citations

Abstract

Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.

Original languageEnglish (US)
Pages (from-to)1066-1068
Number of pages3
JournalCell Cycle
Volume5
Issue number10
DOIs
StatePublished - May 15 2006

Keywords

  • Chromatin
  • Histone methylation
  • P-TEFb
  • RNA polymerase II
  • Transcription elongation

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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