Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb

Adam Wood; Ali Shilatifard

doi:10.4161/cc.5.10.2769

Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb

Adam Wood, Ali Shilatifard^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

51 Scopus citations

Abstract

Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.

Original language	English (US)
Pages (from-to)	1066-1068
Number of pages	3
Journal	Cell Cycle
Volume	5
Issue number	10
DOIs	https://doi.org/10.4161/cc.5.10.2769
State	Published - May 15 2006

Keywords

Chromatin
Histone methylation
P-TEFb
RNA polymerase II
Transcription elongation

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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title = "Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb",

abstract = "Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.",

keywords = "Chromatin, Histone methylation, P-TEFb, RNA polymerase II, Transcription elongation",

author = "Adam Wood and Ali Shilatifard",

note = "Funding Information: The authors would like to thank Kristy Wendt for editorial assistance and critical reading of this review. The work in Shilatifard{\textquoteright}s laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905) and the American Cancer Society. A.W. is supported by a American Heart Association Predoctoral fellowship. A.S. is a Scholar of the Leukemia and Lymphoma Society.",

year = "2006",

month = may,

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doi = "10.4161/cc.5.10.2769",

language = "English (US)",

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T1 - Bur1/Bur2 and the Ctk complex in yeast

T2 - The split personality of mammalian P-TEFb

AU - Wood, Adam

AU - Shilatifard, Ali

N1 - Funding Information: The authors would like to thank Kristy Wendt for editorial assistance and critical reading of this review. The work in Shilatifard’s laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905) and the American Cancer Society. A.W. is supported by a American Heart Association Predoctoral fellowship. A.S. is a Scholar of the Leukemia and Lymphoma Society.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.

AB - Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below.

KW - Chromatin

KW - Histone methylation

KW - P-TEFb

KW - RNA polymerase II

KW - Transcription elongation

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M3 - Short survey

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SN - 1538-4101

VL - 5

SP - 1066

EP - 1068

JO - Cell Cycle

JF - Cell Cycle

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ER -

Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb

Abstract

Keywords

ASJC Scopus subject areas

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