Burden and determinants of severe anemia among HIV-infected adults: Results from a large urban HIV Program in Tanzania, East Africa

Abel Makubi*, James Okuma, Donna Spiegelman, Claudia Hawkins, Anne Marie Darling, Elizabeth Jackson, Ferdinand Mugusi, Guerino Chalamilla, Wafaie Fawzi

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background and Methods: This cross-sectional study aimed at determining the prevalence and risk factors for severe anemia, severe microcytic anemia, and severe normocytic anemia among HIV-infected individuals aged >15 years. Univariate and multivariate analyses were performed to identify the risk factors for anemia. Results: Data from 40 408 patients were analyzed, showing an overall prevalence of 22% for severe anemia. The risk of developing severe anemia increased by 49% among patients with a body mass index of 18.5 kg/m2, by approximately 2-fold among patients with the World Health Organization (WHO) stage III, and by 3-fold among patients with WHO stage IV illness. Severe normocytic anemia was uniquely increased among patients aged ≥50 years, among those with chronic diarrhea and Kaposi's sarcoma, and those taking cotrimoxazole. Conclusion: There was a high prevalence of severe anemia among adults infected with HIV. Focused identification of anemia should be based on the hemoglobin and mean corpuscular volume measurements.

Original languageEnglish (US)
Pages (from-to)148-155
Number of pages8
JournalJournal of the International Association of Providers of AIDS Care
Volume14
Issue number2
DOIs
StatePublished - Mar 20 2015

Keywords

  • HIV
  • adults
  • burden
  • determinants
  • severe anemia

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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