TY - JOUR
T1 - Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the united states
T2 - A patient-centered evaluation
AU - Schaefer, Caroline
AU - Mann, Rachael
AU - Sadosky, Alesia
AU - Daniel, Shoshana
AU - Parsons, Bruce
AU - Nieshoff, Edward
AU - Tuchman, Michael
AU - Nalamachu, Srinivas
AU - Anschel, Alan
AU - Stacey, Brett R.
N1 - Publisher Copyright:
© 2014 American Academy of Pain Medicine 15 12 December 2014 10.1111/pme.12502 Original Research Article NEUROPATHIC PAIN SECTION Original Research Articles Wiley Periodicals, Inc.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective: The aim of this study was to evaluate patient-reported burden associated with peripheral and central neuropathic pain (NeP) by pain severity and NeP condition. Design: Six hundred twenty-four subjects with one of six NeP conditions were recruited during routine office visits. Subjects consented to retrospective chart review and completed a one-time questionnaire (including EuroQol-5 dimensions, 12-item Short-Form Health Survey, Brief Pain Inventory-Short Form, Medical Outcomes Study Sleep Scale, Hospital Anxiety and Depression Scale, and demographic and clinical characteristics). Pain severity scores were used to stratify subjects by mild, moderate, and severe pain. Summary statistics and frequency distributions were calculated. Differences by severity level were compared using Kruskal-Wallis (continuous variables) and chi-square or Fisher's exact test (categorical variables). Effect size was computed with Cohen's d (mild vs severe). Results: Subjects' mean age was 55.5. The majority (80.8%) had moderate or severe pain. Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P<0.0001). Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others. The observed burden was most substantial among chronic low back pain-NeP, although the pattern of disease burden was similar across the six NeP conditions. Conclusions: Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression. Results indicate substantial patient burden across broad NeP, particularly among subjects with severe pain.
AB - Objective: The aim of this study was to evaluate patient-reported burden associated with peripheral and central neuropathic pain (NeP) by pain severity and NeP condition. Design: Six hundred twenty-four subjects with one of six NeP conditions were recruited during routine office visits. Subjects consented to retrospective chart review and completed a one-time questionnaire (including EuroQol-5 dimensions, 12-item Short-Form Health Survey, Brief Pain Inventory-Short Form, Medical Outcomes Study Sleep Scale, Hospital Anxiety and Depression Scale, and demographic and clinical characteristics). Pain severity scores were used to stratify subjects by mild, moderate, and severe pain. Summary statistics and frequency distributions were calculated. Differences by severity level were compared using Kruskal-Wallis (continuous variables) and chi-square or Fisher's exact test (categorical variables). Effect size was computed with Cohen's d (mild vs severe). Results: Subjects' mean age was 55.5. The majority (80.8%) had moderate or severe pain. Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P<0.0001). Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others. The observed burden was most substantial among chronic low back pain-NeP, although the pattern of disease burden was similar across the six NeP conditions. Conclusions: Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression. Results indicate substantial patient burden across broad NeP, particularly among subjects with severe pain.
KW - Burden of illness
KW - Health status
KW - Health-related quality of life
KW - Neuropathic pain
KW - Pain assessment
KW - Patient-reported outcomes
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U2 - 10.1111/pme.12502
DO - 10.1111/pme.12502
M3 - Article
C2 - 25039856
AN - SCOPUS:84919842914
SN - 1526-2375
VL - 15
SP - 2105
EP - 2119
JO - Pain Medicine (United States)
JF - Pain Medicine (United States)
IS - 12
ER -
