TY - JOUR
T1 - Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma
AU - Look, Rogan Mon
AU - Lim, Stephen Wong
AU - Schreck, Rhona Rebecca
AU - Lee, Stephen
AU - Fuerst, Marie Perrelli
AU - Lawrence, Grace Natividad
AU - Kusuanco, Donato Absalom
AU - Kessler, Christine Elisabeth
AU - Giles, Francis Joseph
PY - 1995/7/15
Y1 - 1995/7/15
N2 - The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.
AB - The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.
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U2 - 10.1016/0165-4608(95)00049-U
DO - 10.1016/0165-4608(95)00049-U
M3 - Article
C2 - 7664237
AN - SCOPUS:0029149527
SN - 0165-4608
VL - 82
SP - 100
EP - 102
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
