Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man

H. S. Lee*, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Buspirone, a putative serotonin (5-HT)1A partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. Thus, buspirone may be a weaker agonist at those 5-HT1A receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-HT1A partial agonists which have been reported to produce hypothermia by a 5-HT1A-mediated mechanism.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of Neural Transmission
Issue number1
StatePublished - Feb 1991


  • 5-HT receptor
  • Buspirone
  • DA receptor
  • body temperature

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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