Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man

H. S. Lee; H. Y. Meltzer

doi:10.1007/BF01250377

Buspirone does not produce a 5-HT_1A-mediated decrease in temperature in man

H. S. Lee^*, H. Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Buspirone, a putative serotonin (5-HT)_1A partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. Thus, buspirone may be a weaker agonist at those 5-HT_1A receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-HT_1A partial agonists which have been reported to produce hypothermia by a 5-HT_1A-mediated mechanism.

Original language	English (US)
Pages (from-to)	71-76
Number of pages	6
Journal	Journal of Neural Transmission
Volume	86
Issue number	1
DOIs	https://doi.org/10.1007/BF01250377
State	Published - Feb 1991

Keywords

5-HT receptor
Buspirone
DA receptor
body temperature

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF01250377

Cite this

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