Buspirone-induced prolactin secretion in man is not 5-HT(1A) receptor mediated: Effect of pindolol pretreatment

H. S. Lee*, J. F. Nash, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The effect of the nonbenzodiazepine anxiolytic, buspirone (Buspar®), a serotonin (5-HT)(1A) partial agonist, which also has dopamine (DA)2 receptor antagonist properties, on prolactin and cortisol secretion was examined in eight normal male volunteers. The oral administration of buspirone (30 mg) significantly increased plasma prolactin concentrations but did not significantly increase plasma cortisol concentrations in this study. The oral administration of pindolol (30 mg), a beta adrenoceptor antagonist which is also a 5-HT(1A) receptor antagonist, had no significant effect on basal prolactin or cortisol levels. Moreover, pretreatment with pindolol did not significantly inhibit the buspirone-induced increase in prolactin secretion. These preliminary data are suggestive that buspirone-induced prolactin secretion is not mediated via 5-HT(1A) receptor activation.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalKorean Journal of Pharmacology
Volume28
Issue number1
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Buspirone-induced prolactin secretion in man is not 5-HT(1A) receptor mediated: Effect of pindolol pretreatment'. Together they form a unique fingerprint.

  • Cite this