C-18 Hydroxylation of gibberellins

Lewis N. Mander; Regan J. Thomson

doi:10.1039/b006044p

C-18 Hydroxylation of gibberellins

Lewis N. Mander^*, Regan J. Thomson

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA₄ methyl ester by means of a tandem process involving the conjugate addition of alkoxide to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.

Original language	English (US)
Pages (from-to)	2893-2894
Number of pages	2
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	17
DOIs	https://doi.org/10.1039/b006044p
State	Published - 2000

ASJC Scopus subject areas

General Chemistry

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title = "C-18 Hydroxylation of gibberellins",

abstract = "A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 methyl ester by means of a tandem process involving the conjugate addition of alkoxide to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.",

author = "Mander, {Lewis N.} and Thomson, {Regan J.}",

year = "2000",

doi = "10.1039/b006044p",

language = "English (US)",

pages = "2893--2894",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1470-4358",

publisher = "Chemical Society",

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T1 - C-18 Hydroxylation of gibberellins

AU - Mander, Lewis N.

AU - Thomson, Regan J.

PY - 2000

Y1 - 2000

N2 - A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 methyl ester by means of a tandem process involving the conjugate addition of alkoxide to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.

AB - A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 methyl ester by means of a tandem process involving the conjugate addition of alkoxide to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.

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U2 - 10.1039/b006044p

DO - 10.1039/b006044p

M3 - Article

AN - SCOPUS:0034618933

SN - 1470-4358

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EP - 2894

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 17

ER -

C-18 Hydroxylation of gibberellins

Abstract

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