A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 methyl ester by means of a tandem process involving the conjugate addition of alkoxide to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - Dec 1 2000|
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