TY - JOUR
T1 - C-kit receptor expression in acute leukemias - Association with patient and disease characteristics and with outcome
AU - Tsao, Anne S.
AU - Kantarjian, Hagop
AU - Thomas, Deborah
AU - Giles, Francis
AU - Cortes, Jorge
AU - Garcia-Manero, Guillermo
AU - Huh, Yang
AU - Yang, Ying
AU - Shen, Yu
AU - Albitar, Maher
AU - Estey, Elihu
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004/4
Y1 - 2004/4
N2 - We hypothesize that c-kit expression may be associated with disease-specific features and have prognostic value in acute leukemias. In acute lymphocytic leukemia (ALL), higher levels of c-kit expression predicted lower complete response (CR) rates, suggesting that these patients may benefit from acute myelogenous leukemia (AML) therapy. Despite a negative association with the Philadelphia-chromosome, there was no correlation with disease-free survival (DFS) in CR. In AML, c-kit was associated with older age and cytogenetic abnormality t(-5, -7). Consequently higher levels of c-kit predicted lower CR rates. However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR.
AB - We hypothesize that c-kit expression may be associated with disease-specific features and have prognostic value in acute leukemias. In acute lymphocytic leukemia (ALL), higher levels of c-kit expression predicted lower complete response (CR) rates, suggesting that these patients may benefit from acute myelogenous leukemia (AML) therapy. Despite a negative association with the Philadelphia-chromosome, there was no correlation with disease-free survival (DFS) in CR. In AML, c-kit was associated with older age and cytogenetic abnormality t(-5, -7). Consequently higher levels of c-kit predicted lower CR rates. However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR.
KW - Acute lymphocytic leukemia (ALL)
KW - Acute myelogenous leukemia (AML)
KW - C-kit
KW - Martingale residual plots
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U2 - 10.1016/j.leukres.2003.09.008
DO - 10.1016/j.leukres.2003.09.008
M3 - Article
C2 - 15109537
AN - SCOPUS:10744227578
SN - 0145-2126
VL - 28
SP - 373
EP - 378
JO - Leukemia Research
JF - Leukemia Research
IS - 4
ER -
